Comparison of the pulmonary, hepatic and renal extraction of PGI2 and 6-KETO-PGE1
References (12)
- et al.
A comparison of the pulmonary, renal and hepatic extractions of PGI2 and PGE2-PGI2 a potential circulating hormone
Life Sci.
(1978) - et al.
Hypotensive and renovascular actions of 6-keto-prostaglandin E1, a metabolite of prostacyclin
European J. Pharmacol.
(1979) - et al.
Prostaglandins and renin release: I. Stimulation of renin release from rabbit renal cortical slices by PGI2
Prostaglandins
(1977) - et al.
Hepatic metabolism of prostacyclin in the rabbit: Formation of a potent novel inhibitor of platelet aggregation
Biochem. Biophys. Res. Commun.
(1980) - et al.
6-keto-prostaglandin E1 inhibits the aggregation of human platelets
European J. Pharmacol.
(1979) - et al.
Recirculation of prostacyclin (PGI2) in the dog
Br. J. Pharmacol.
(1978)
There are more references available in the full text version of this article.
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Recent advances in studies of SLCO2A1 as a key regulator of the delivery of prostaglandins to their sites of action
2021, Pharmacology and TherapeuticsCitation Excerpt :Since then, evidence has accumulated that uptake of PGs such PGE1, PGE2, PGD2, and PGF2α by the lungs is non-linear (Linehan & Dawson, 1979; Piper, Vane, & Wylllie, 1970; Robinson & Hoult, 1982), dependent upon plasma protein binding (C. A. Dawson, Linehan, Rickaby, & Roerig, 1984), and accompanied with rapid metabolism (C. A. Dawson, Cozzini, & Lonigro, 1975). However, metabolites of PGI2 or 6-keto PGF1α were hardly detectable in the lungs (Dusting et al., 1978; Tsunoda, Jackson, Branch, & Gerkens, 1982). Primary metabolites of PGs (15-keto PG and 13,14-dihydro 15-keto PG, Fig. 3B) appeared in the lungs after intravenous infusion, and their appearance was blocked by drugs such as indocyanine green (Pitt, Forder, & Gillis, 1983).
Prostaglandin transport
2002, Prostaglandins and Other Lipid MediatorsFollow-up of prostaglandin plasma levels after acute myocardial infarction
1985, American Heart JournalBiological activities of 6-keto-prostaglandin E<inf>1</inf>
1984, Prostaglandins, Leukotrienes and Medicine9-hydroxyprostaglandin dehydrogenase in rat kidney cortex converts prostaglandin I<inf>2</inf> into 15-keto-13,14-dihydro 6-ketoprostaglandin E<inf>1</inf>
1984, Biochimica et Biophysica Acta (BBA)/Lipids and Lipid MetabolismEnzymatic inactivation of 6-keto-prostaglandin E<inf>1</inf> in vitro: Comparison with prostaglandin E<inf>1</inf>
1984, Biochemical Pharmacology
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