Behavioural and neurochemical effects of medetomidine, a novel veterinary sedative
References (25)
- et al.
Pharmacological evidence for a stimulation of dopamine neurons by noradrenergic neurons in the brain
European J. Pharmacol.
(1976) - et al.
Simultaneous determination of noradrenaline and 3-methoxy-4-hydroxyphenylethyleneglycol sulfate in discrete brain regions of the rat
Anal. Biochem.
(1979) Applications of high performance liquid chromatography with electrochemical detection to neurochemical analysis: measurement of catecholamine, serotonin and metabolites in rat brain
J. Neurosci. Methods
(1981)- et al.
Comparison of free MHPG in rat cerebrospinal fluid with free and conjugated MHPG in brain tissue: effects of drugs modifying noradrenergic transmission
European J. Pharmacol.
(1986) - et al.
Behavioural and neurochemical effects of atipamezole, a novel α2-adrenoceptor antagonist
European J. Pharmacol.
(1988) - et al.
Repetitive measurement of monoamine metabolite levels in cerebrospinal fluid of conscious rats: effects of reserpine and haloperidol
European J. Pharmacol.
(1985) - et al.
α2-Adrenoceptor agonists decrease free 3-methoxy-4-hydroxy-phenyl-glycol in rat cerebrospinal fluid
European J. Pharmacol.
(1986) - et al.
Inhibition of both noradrenergic and serotonergic neurons in brain by the α-adrenergic agonist clonidine
Brain Res.
(1975) - et al.
Characterization of α-adrenoceptors participating in the central hypotensive and sedative effects of clonidine using yohimbine, rauwolscine and corynanthine
European J. Pharmacol.
(1981) - et al.
Characterization of the selectivity, specificify and potency of medetomidine as an α2-adrenoceptor agonist
European J. Pharmacol.
(1988)
Different α-adrenoceptors in the central nervous system mediating biochemical and functional effects of clonidine and receptor blocking agents
Naunyn-Schmiedeb. Arch. Pharmacol.
Isolation and purification of clonidine-displacing endogenous brain substance
European J. Biochem.
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Cardiovascular effects of intravenous vatinoxan (MK-467) in medetomidine–tiletamine–zolazepam anaesthetised red deer (Cervus elaphus)
2020, Veterinary Anaesthesia and AnalgesiaCitation Excerpt :A decrease in RT over time was observed in the present study, although no hypothermia (RT <37°C) was detected. Hypothermia can occur in sedated and anaesthetised animals because of impaired thermoregulation and decreased metabolic activity (MacDonald et al. 1988; Grimm & Lamont 2007). In the present study, RT decreased significantly from baseline with both treatments.
Do heat and moisture exchangers in the anaesthesia breathing circuit preserve body temperature in dogs undergoing anaesthesia for magnetic resonance imaging?
2017, Veterinary Anaesthesia and AnalgesiaA novel bioassay for evaluating the efficacy of biocides to inhibit settling and early establishment of marine biofilms
2014, Marine Pollution BulletinCitation Excerpt :TPBP is an organoborane compound mainly used in Japan (Thomas and Langford, 2009) where it has been a common antifouling biocide since 1995 (Mochida et al., 2012). Medetomidine (4-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole) is traditionally used within veterinary medicine as a sedative agent (Macdonald et al., 1988). Dahlstrom et al. (2000) discovered that medetomidine inhibits barnacle settling at low concentrations and it is now approved as an antifouling biocide in Japan under the trade name Selektope® (Ohlauson and Blanck, 2014).
Developmental and behavioral effects of medetomidine following in ovo injection in chicks
2012, Neurotoxicology and TeratologyCitation Excerpt :Medetomidine is usually combined with ketamine to produce general anesthesia in dogs, cats and avian species (Short, 1992; Cornick-Seahorn, 2001; Sinclair, 2003; Ansah, 2004; Murrell and Hellebrekers, 2005). The pharmacological effects of medetomidine are mediated via activation of alpha-2 adrenoceptors resulting in reduced catecholamine release and turnover (MacDonald et al., 1988, 1989; Virtanen, 1989; Virtanen et al., 1989). The side effects of medetomidine in animals are characterized by bradycardia, hypoventilation, urination, salivation, hypothermia and hypotension (MacDonald et al., 1989; Mohammad et al., 1991; Short, 1992; Mohammad et al., 1993b, 1995; Cornick-Seahorn, 2001; Sinclair, 2003; Ansah, 2004).
Sedative and cardiorespiratory effects of dexmedetomidine and buprenorphine administered to cats via oral transmucosal or intramuscular routes
2010, Veterinary Anaesthesia and AnalgesiaCitation Excerpt :After medication, heart rate decreased significantly in both groups. The decrease might have been due to two known dexmedetomidine‐induced phenomena: an increase in arterial blood pressure inducing a baroreceptor‐mediated increase in vagal outflow causing bradycardia, or a decrease in sympathetic tone due to dexmedetomidine‐mediated decrease in norepinephrine release in the CNS (MacDonald et al. 1988; Ansah et al. 1998). It is possible that we did not observe an increase in SAP after dexmedetomidine in our cats because SAP was already increased by handling and environmental factors before the dexmedetomidine was given.