Short communicationNeuromedin U octapeptide alters ion transport in porcine jejunum
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Distribution and characterization of neuromedin U-like immunoreactivity in rat brain and intestine and in guinea pig intestine
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Characterization of neuromedin U like immunoreactivity in rat, porcine, guinea-pig and human tissue extracts using a specific radioimmunoassay
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Neuromedin U-8 and U-25: novel uterus stimulating and hypertensive peptides identified in porcine spinal cord
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Cited by (68)
Circulating neuromedin U levels are similar in subjects with NGT and newly diagnosed T2DM and do not correlate with insulin secretion
2019, Diabetes Research and Clinical PracticeIdentification and immunoregulatory function of neuromedin U (Nmu) in the Japanese pufferfish Takifugu rubripes
2017, Developmental and Comparative ImmunologyCitation Excerpt :The primarily identified biological functions of NMU included control of contraction of uterus smooth muscle and regulation of arterial blood pressure (Minamino et al., 1985). Thereafter, its involvement in other biological activities, including the regulation of stress response (Malendowicz et al., 1993), alteration of ion transport in the jejunum (Brown and Quito, 1988), reduction of food intake and body weight (Howard et al., 2000), involvement in the circadian oscillator system (Nakahara et al., 2004), insulin secretion (Kaczmarek et al., 2006), and bone remodeling (Sato et al., 2007), were revealed in mammals. Moreover, it has been reported that NMU plays a role in immune regulation (especially inflammation), such as activation of macrophages indicated by in vivo analysis using NMU-deficient mice (Moriyama et al., 2006b) and cytokine release in a mouse Th2-type cell line (D10.G4.1) (Johnson et al., 2004), activation of eosinophils (Moriyama et al., 2006a), direct activation of mast cells (Moriyama et al., 2005) exhibited by in vivo analysis using NMU-deficient mice and the involvement of NMU receptor subtype1 (NMU1R) in inflammatory regulation demonstrated by in vivo analysis using NNU1R-deficient mice (Abbondanzo et al., 2009).
Neuromedin: An insight into its types, receptors and therapeutic opportunities
2017, Pharmacological ReportsCitation Excerpt :Electrogenic ions consist of Ca2+, Na2+, K+ for this electrogenic pumps play a very important role. The whole process is mediated by external Cl− and is controlled by noncholinergic enteric neurons [83]. NMU-R1 receptors are present in immune cells which suggest of NMU playing an important role in immunomodulation.
Neuromedin U inhibits food intake partly by inhibiting gastric emptying
2015, PeptidesCitation Excerpt :Similar short-lived effects on food intake and body weight have also been described for other gut-brain peptides such as neurotensin, xenin and cholecystokinin (CCK) [34,35]. Repeated in vitro administration of NMU8 to isolated porcine jejunum has been shown to lead to tachyphylaxis [36]. Similarly, the contractile response of human isolated ileum was also characterized by the development of tachyphylaxis following repeated application of NMU8 [37].
Design, synthesis and biological activity of flavonoid derivatives as selective agonists for neuromedin U 2 receptor
2014, Bioorganic and Medicinal ChemistryCitation Excerpt :Neuromedin U (NMU) regulates a variety of physiological activities in mammals, including stimulation of smooth-muscle contraction,1 blood pressure regulation,2 ion transport,3,4 local blood flow control,5 gastric acid secretion and gastric emptying.6