Effects and aftereffects of ibogaine on morphine self-administration in rats
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2023, Pharmacological Research(+)-Catharanthine and (-)-18-methoxycoronaridine induce antidepressant-like activity in mice by differently recruiting serotonergic and norepinephrinergic neurotransmission
2023, European Journal of PharmacologyCitation Excerpt :The results show that repeated treatments with 20 mg/kg of (+)-catharanthine or (-)-18-MC induced the same level of antidepressant-like activity compared to that for acute treatment using a dose of 40 mg/kg, indicating that prolonged treatments increase drug efficacy without inducing tolerance. The same trend was observed for the anti-addictive activity of 18-MC after prolonged treatment (Glick et al., 1991). The lack of sex-dependence in the antidepressant-like activity of both (+)-catharanthine and (-)-18-MC suggests that hormonal and neurochemical differences between male and female mice are not important for the antidepressant-like activity of coronaridine congeners.
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