Effects on ingestive behavior in rats of the α1-adrenoceptor agonist cirazoline
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2017, Pharmacology and TherapeuticsCitation Excerpt :Expression of α2-adrenoceptors in paraventricular nucleus is under circadian control, with increased expression at dark phase onset, when feeding behavior in rodents is increased (Wellman, 2000). In contrast to the hyperphagic effect of α2-adrenoceptor stimulation, injection of α1-adrenoceptor agonist, cirazoline (3–24 nmol) into paraventricular nucleus suppressed food intake in rats, compared to control (Davies & Wellman, 1992). Taken together, these results suggest that the relative balance of α1- and α2-adrenoceptors within the paraventricular nucleus modulates the impact of various adrenergic agonists on feeding.
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