ucb L059, a novel anti-convulsant drug: pharmacological profile in animais
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Cited by (199)
Combination of levetiracetam with sodium selenite prevents pentylenetetrazole-induced kindling and behavioral comorbidities in rats
2022, Saudi Pharmaceutical JournalCitation Excerpt :Se was found capable to cause prominent latency in developing the myoclonic jerks and generalized seizures and polytherapy were found superior to monotherapy. These results are in agreement with the previous study carried out by Grover et al. in which LEV inhibited the development of PTZ-kindling in rodents (Gower et al., 1992). Similarly, Loscher et al. also reported the anti-epileptogenic effects of LEV in which drug inhibited the expression of seizures dose-dependently in the amygdala–kindled rats (Löscher et al., 1998).
The piriform cortex in epilepsy: What we learn from the kindling model
2020, Experimental NeurologyLevetiracetam combined with ACEA, highly selective cannabinoid CB1 receptor agonist changes neurogenesis in mouse brain
2019, Neuroscience LettersCitation Excerpt :It is a unique antiepileptic drug in that is ineffective in classic seizure models which screen potential compounds for antiseizure efficacy such as maximal electroshock and pentylenetetrazol in rodents [2–5]. On the other hand it was proven that during preclinical evaluations, it increased the threshold for electroconvulsions and suppressed seizures in kindled and genetically epileptic animals [6–11]. Levetiracetam has also shown protective activity against acute seizures induced by 6 Hz electrical stimulation - a model of psychomotor seizures [12–14].
Neuroprotective effects of levetiracetam, both alone and combined with propylparaben, in the long-term consequences induced by lithium-pilocarpine status epilepticus
2018, Neurochemistry InternationalCitation Excerpt :LEV is used as monotherapy and adjunctive therapy for the treatment of refractory partial seizures, juvenile myoclonic epilepsy and generalized idiopathic tonic-clonic seizures (Aiguabella et al., 2011; Lyseng-Williamson, 2011). Using experimental models, it has been described that LEV diminishes audiogenic seizures and delays the epileptogenesis process induced by amygdala-kindling (Gower et al., 1992; Löscher et al., 1998). The administration of LEV during status epilepticus (SE) reduces the duration of seizure activity (Itoh et al., 2015; Lee et al., 2013; Mazarati et al., 2004; Oliveira et al., 2005; Zheng et al., 2010).