Rapid communicationIsoflurane anesthesia is stereoselective
References (8)
- et al.
Optical rotary dispersion of hemoglobin and polypeptides effect of halothane
J. Biol. Chem.
(1971) The nature of site of general anesthesia
Int. Rev. Neurobiol.
(1985)- et al.
Effects of two benzodiazepine inverse agonists, RO 15-4513 and FG 7142, on recovery from pentobarbital and halothane anesthesia in the rat
Pharmacol. Biochem. Behav.
(1990) Criteria for receptor identification
Cited by (85)
Electrophysiological-mechanical coupling in the neuronal membrane and its role in ultrasound neuromodulation and general anaesthesia
2019, Acta BiomaterialiaCitation Excerpt :For instance, although the luciferase model was instrumental in suggesting that general anaesthetics could have direct competitive inhibitory effects on enzymatic functions, it is not an adequate model to explain pressure reversal [220]. The anaesthetic potency of isoflurane [129,194] varies between its two stereoisomers as does their ability to modulate GABAA receptor opening [213]. Similar effects are found with other chiral anaesthetic agents such as ketamine.
Isoflurane does not aggregate inside POPC bilayers at high pressure: Implications for pressure reversal of general anaesthesia
2015, Chemical Physics LettersCitation Excerpt :Pharmacodynamic effects are site-specific. This possibility was supported by the finding that general anaesthetics were found to be enantiospecific, but this enantiospecificity cannot be accounted for by their effects on the cell membrane [29–32]. The membrane is thus unlikely to be the site of action of general anaesthetics.
Benzodiazepine-like discriminative stimulus effects of toluene vapor
2013, European Journal of PharmacologyBiophysical changes induced by xenon on phospholipid bilayers
2013, Biochimica et Biophysica Acta - BiomembranesCitation Excerpt :However, specific protein targets for a lipid membrane-mediated mechanism of general anesthetic action have not been proposed so this mechanism remains speculative. Furthermore, as of yet, Cantor's lateral pressure profile hypothesis does not account for the fact that some general anesthetic agents, such as isoflurane [98,99], are chiral molecules, with different enantiomers exhibiting different anesthetic potencies. While chiral molecules do exist in many membranes, no lipid membrane-mediated mechanism accounting for the observed stereospecificity has been proposed [42].
A possible molecular mechanism for the pressure reversal of general anaesthetics: Aggregation of halothane in POPC bilayers at high pressure
2012, Chemical Physics LettersCitation Excerpt :Since the sites of action of chlorpromazine and lignocaine are known to be different from the putative site of action of general anaesthetics, it appears that pressure reversal is a pharmacokinetic effect, rather than a pharmacodynamic effect. This possibility was supported by the finding that general anaesthetics were found to be stereospecific, but this stereospecificity cannot be accounted for by their effects on the cell membrane [33–36]. The membrane is thus unlikely to be the site of action of general anaesthetics.
Pressure reversal of general anaesthetics: A possible mechanism from molecular dynamics simulations
2009, Journal of Molecular Liquids