Short communicationGlutamate participates in the peripheral modulation of thermal hyperalgesia in rats
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2018, Food and Chemical ToxicologyCitation Excerpt :Glutamate is one of the prevalent excitatory neurotransmitter found in CNS (Coderre, 1993). There are lots of evidences about the excess accumulation of glutamate after injury at the spinal cord or after certain inflammatory process which play a relevant role in pain transmission (Jackson et al., 1995). The N-methyl-d-aspartate (NMDA), Amino-5-Methyl-4-isoxazole-Propionic Acid (AMPA) and Kainite receptors which are ligand-gated ion channels play an important role in glutamate mediated pain (Beirith et al., 2002; Alves and Duarte, 2002; Bleakman et al., 2006; Carlton, 2001; Minami et al., 2001; Neugebauer, 2001).
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2018, Food Research InternationalCitation Excerpt :Similar results were also reported for thermal hyperalgesia, which is induced by inflammatory stimuli such as carrageenan and prostaglandin E2 (Peana et al., 2004). These inflammatory stimuli produce inflammatory response that lead to hyperalgesic condition via the increasing glutamate production in spinal cord (Jackson, Graff, Richardson, & Hargreaves, 1995) and activating many relevant key players such as NMDA, substance P, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA), and kainate receptors (Batista et al., 2008; Turnbach & Randich, 2002). In addition, the mice model demonstrated that (−)-linalool exhibited antinociceptive effect against persistent pain conditions such as chronic inflammatory pain and neuropathic pain (Batista et al., 2010).
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