Colonic motility and transit in health and ulcerative colitis

doi:10.1016/0016-5085(91)90079-Z

Gastroenterology

Volume 101, Issue 5, November 1991, Pages 1289-1297

https://doi.org/10.1016/0016-5085(91)90079-Z Get rights and content

Abstract

Preprandial and postprandial colonic motility and transit (scintigraphy), with respect to the splenic flexure, were studied in 10 patients with ulcerative colitis and in 9 healthy subjects. The healthy subjects had a postprandial increase in intraluminal pressure that was significantly (P < 0.03) greater in the descending colon than in other regions of the colon. In ulcerative colitis, the pressure was decreased in all regions compared with healthy subjects, with no significant pressure gradient among different regions. In normal subjects, transit was quiescent during fasting; eating stimulated both antegrade and retrograde transit. In ulcerative colitis, transit was variable before as well as after the meal. Both healthy subjects and patients with ulcerative colitis had more rapid emptying from the splenic flexure into the sigmoid than into the transverse colon. More frequent, low-amplitude, postprandial propagating contractions occurred in ulcerative colitis (P < 0.05) than in healthy subjects. Propagating contractions were always antegrade and caused a rapid movement of the tracer into the sigmoid. In conclusion, ulcerative colitis is characterized by (a) decreased contractility, (b) increased low-amplitude propagating contractions, and (c) variable transit. These disturbances may accentuate the diarrhea in ulcerative colitis.

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: The results of this study were presented in part at the American Gastroenterological Association meeting in Washington, D.C., in May 1989.

¹: Supported in part by the Inflammatory Bowel Disease Center and in part by UCLA—Harbor Collegium Research Award to S. Narasimha Reddy.

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Colonic motility and transit in health and ulcerative colitis

Abstract

Gastroenterology

Gastroenterology

Gastroenterology

Gastroenterology

Gastroenterology

Studies on the mechanism of bowel disturbance in ulcerative colitis

Gastroenterology

The motility of the distal colon in non-specific ulcerative colitis

Gastroenterology

The motility of the pelvic colon. Part 2. Paradoxical motility in diarrhea and constipation

Gut

Effect of eating and gastrointestinal hormones on human colonic myoelectric and motor activity

Gastroenterology