Dietary saturated fatty acids: A novel treatment for alcoholic liver disease☆
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Cited by (96)
Alcohol effects on hepatic lipid metabolism
2020, Journal of Lipid ResearchFish oil up-regulates hepatic autophagy in rats with chronic ethanol consumption
2020, Journal of Nutritional BiochemistryRole of dietary fatty acids in liver injury caused by vinyl chloride metabolites in mice
2016, Toxicology and Applied PharmacologyDietary saturated lipids in alcoholic liver disease: New microbiota-targeting bullets?
2015, GastroenterologySupplementation of saturated long-chain fatty acids maintains intestinal eubiosis and reduces ethanol-induced liver injury in mice
2015, GastroenterologyCitation Excerpt :Our findings indicate that alterations in metabolism by the intestinal microbiota contribute to the pathogenesis of alcoholic liver disease. Although studies have described the protective effects of different dietary mixtures of fats containing SFs,30–35 their relevance to human disease and mechanisms were not determined. We demonstrate the mechanisms by which alcohol disrupts the intestinal microbiome and its metabolome to contribute to liver disease.
Alcoholic and non-alcoholic steatohepatitis
2014, Experimental and Molecular PathologyCitation Excerpt :Dietary fat and alcohol both play important roles in the pathogenesis of ALD. Several studies have shown that dietary saturated fat protects against alcohol-induced liver disease in rodents, whereas dietary unsaturated fat, enriched in linoleic acid (LA) in particular, promotes alcohol-induced liver damage (Nanji and French, 1989; Nanji et al., 1989, 1995b, 2001). The deleterious effects of dietary unsaturated fatty acids are thought to be mediated through induction of oxidative stress, potentiated by inducing CYP2E1 (Nanji et al., 1994b, 1994c, 1995a), elevated endotoxin levels, and increased production of proinflammatory cytokines (Nanji, 2004).
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Supported by grants from the Palm Oil Research Institute of Malaysia and grants DK33765 and DK01992 from the National Institutes of Health.