Elsevier

Atherosclerosis

Volume 80, Issue 2, December 1989, Pages 143-147
Atherosclerosis

Research paper
Antiproliferative action of cyclic GMP-elevating vasodilators in cultured rabbit aortic smooth muscle cells

https://doi.org/10.1016/0021-9150(89)90022-1Get rights and content

Abstract

In cultured rabbit aortic smooth muscle cells (SMCs), sodium nitroprusside (SNP) (10−7 to 10−4 M), atrial natriuretic peptide (ANP) (10−9 to 10−6 M) and 8-bromo-cyclic GMP (10−6 to 10−3 M) inhibited the whole blood serum (WBS)-induced DNA synthesis by about 30%. The doses of SNP and ANP necessary for the inhibition of the WBS-induced DNA synthesis were similar to those necessary for the formation of cellular cyclic GMP (cGMP). These agents were effective even when added 6 h after stimulation of the cells with WBS. These results suggest that cGMP inhibits the proliferation of rabbit aortic SMCs by inhibiting the progression from the G 1 into S phase of the cell cycle and raise the possibility that cGMP-elevating vasodilators may suppress the atherogenic process by inhibiting vascular SMC proliferation.

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