Journal of Molecular Biology
Synergism of closely adjacent estrogen-responsive elements increases their regulatory potential☆
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Cited by (95)
Mechanistic insights into induction of vitellogenin gene expression by estrogens in Sydney rock oysters, Saccostrea glomerata
2016, Aquatic ToxicologyCitation Excerpt :In another study, ERα was shown to cooperatively bind to tandem half-EREs (in the presence of the coactivator protein GMGB1) and activate transcription driven by tandem half-EREs in a synergic manner (Joshi et al., 2011). These findings agree with the concept that closely spaced EREs tend to interact cooperatively as an estrogen response unit (ERU) and confer transcriptional synergism (Beekman et al., 1991; Klein-Hitpass et al., 1988). It is, therefore, tempting to speculate that the three half-EREs residing in the sgVtg promoter may interact and function in a similar fashion.
A distal estrogen responsive element upstream the cap site of human transthyretin gene is an enhancer-like element upon ERα and/or ERβ transactivation
2013, GeneCitation Excerpt :Non-functional palindromic, half-palindromic and imperfect non-palindromic consensus ERE have been identified in several genes. Many of these elements are also functional and are responsible for gene responses to estrogen in an orientation- and distance-independent manner, acting as enhancers or silencers (Berry et al., 1989; Burt et al., 1989; Gaub et al., 1990; Klein-Hitpass et al., 1988a; Muller et al., 2009; Rishi et al., 1995; Seiler-Tuyns et al., 1986). There is also evidence that these functional elements, depending on their number of copies, spacing, distance and orientation may have different effects on the regulation of gene expression (Naar et al., 1991; Hyder et al., 2000; Klinge, 2001; Tyulmenkov and Klinge, 2001b).
Proteomic analysis of coregulators bound to ERα on DNA and Nucleosomes reveals coregulator dynamics
2013, Molecular CellCitation Excerpt :First, we tested how the number of EREs influenced CoR binding by incubating 1x, 2x, 3x, or 4x EREs immobilized on Dynabeads with HNE and E2-liganded ERα. Consistent with reports that more EREs create a transcriptional “synergistic” response (Klein-Hitpass et al., 1988), we found that four EREs promoted optimal binding of CBP, p300, SRCs, and subunits of the Mediator (MED) complex to E2-liganded ERα (see Figure S1A online; data not shown). We also tested whether a functional RNA Pol II promoter (from the Adenovirus E4 gene) fused to 4xEREs (referred to as 4xERE-E4) would further stabilize CoR complex formation, as it has been used widely in binding and in vitro transcription assays (Acevedo et al., 2004).
Control of vitellogenin genes expression by sequences derived from transposable elements in rainbow trout
2010, Biochimica et Biophysica Acta - Gene Regulatory MechanismsCitation Excerpt :VTG are usually encoded by small multigene families which mostly form a vtg gene cluster in a conserved syntenic group [21]. The promoter structure of vtg genes is generally quite simple [15,16,19,22,23], consisting of a consensus or imperfect EREs plus additional enhancers located close to the transcriptional start site (TSS). In salmonids, two paralogous vtg gene clusters arose from an ancestral tetraploïdization, at the base of salmonid radiation.
What are comparative studies telling us about the mechanism of ERβ action in the ERE-dependent E2 signaling pathway?
2008, Journal of Steroid Biochemistry and Molecular Biology
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This work was supported by the Deutsche Forschungsgemeinschaft (Ry ).