Elsevier

Journal of Molecular Structure

Volume 126, January 1985, Pages 509-524
Journal of Molecular Structure

Rotational isomerism in molecules of genetic interest

https://doi.org/10.1016/0022-2860(85)80138-1Get rights and content

Abstract

In this paper the role of Raman Spectroscopy and Circular Dichroism in the determination of the secondary structure of nucleic acids as a function of base composition and interaction with platinum anticancer drugs is discussed. It is pointed out that these various differences in secondary structure occur because of different rotational isomers which are present in these biologically active large molecules.

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