Elsevier

Life Sciences

Volume 39, Issue 12, 22 September 1986, Pages 1043-1050
Life Sciences

Skin permeability of various non-steroidal anti-inflammatory drugs in man

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Abstract

The skin permeabilities of a series of eight salicylates and ten non-steroidal anti-inflammatory drugs were investigated in human subjects. The logarithms of % absorption through intact skin and of n-octanol/water partition coefficients (log P) of the test compounds were plotted against one another, and a parabolic relationship was obtained in both compound series.

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