MinireviewIs migraine prophylactic activity caused by 5-HT2B or 5-HT2C receptor blockade?
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Cited by (74)
Serotonin and cardiovascular diseases
2018, Serotonin: The Mediator that Spans EvolutionBF-1 - A novel selective 5-HT<inf>2B</inf> receptor antagonist blocking neurogenic dural plasma protein extravasation in guinea pigs
2015, European Journal of PharmacologyCitation Excerpt :While the need for acute migraine treatment is fairly well served by triptans, ergotamines, anticonvulsants, non-steroidal anti-inflammatory drugs (NSAIDs) or β-blockers, prophylactic treatment is far from satisfactory. Several pharmaceutical agents have been applied in prophylactic migraine treatment, such as propranolol ((RS)-1-(isopropylamino)-3-(naphthalen-1-yloxy)propan-2-ol), methysergide, pizotifen or amitriptyline (3-(10,11-Dihydro-5H-dibenzo[a,d] cyclohepten-5-yliden)-N,N-dimethylpropylamin) (Fozard and Kalkmann, 1994; Kalkman, 1994; Fozard, 1995). They share antagonistic potency at 5-HT2B receptors, which is believed to be responsible for the effect (Schmuck et al., 1996).
Psilocybin dose-dependently causes delayed, transient headaches in healthy volunteers
2012, Drug and Alcohol DependenceCitation Excerpt :Receptors that trigger migraine attack (possibly 5-HT2B) appear to be different from those that relieve migraine headache (5-HT1 family). The ability of the 5-HT2B/C receptor agonist m-chlorophenylpiperazine (mCPP) to induce attacks in migraine sufferers that are indistinguishable from spontaneous headaches (Brewerton et al., 1988), together with the 5-HT2B affinity of prophylactic antimigraine 5-HT2 receptor antagonists such as methysergide, cyproheptadine, and mianserin, support the involvement of 5-HT2B supersensitivity in migraine attacks (Fozard and Kalkman, 1994; Kalkman, 1994; Schmuck et al., 1996). Triptans are a novel class of selective 5-HT1B/1D antagonists that are the mainstay of current acute migraine treatment.
Pathophysiological basis of migraine prophylaxis
2009, Progress in NeurobiologyNeurogenic Vascular Responses in the Dura Mater and their Relevance for the Pathophysiology of Headaches
2009, NeuroImmune BiologyCitation Excerpt :It is therefore not surprising that 5-HT receptor agonists can either initiate or abort migraine attacks. Cerebrovascular endothelial 5-HT2B receptors have been suggested to be activated at the beginning of a migraine attack [107,108]. 5-HT2 receptor antagonists are therefore used in the prophylaxis of migraine.
Neuroleptics in the treatment of migraine
2008, Medicina Clinica