Serum branched chain amino and keto acid response to fasting in humans☆
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Machine learning approach identifies meconium metabolites as potential biomarkers of neonatal hyperbilirubinemia
2022, Computational and Structural Biotechnology JournalCitation Excerpt :Here, we collected the first postnatal stool, which reflected the prenatal and immediate postnatal metabolic status. Starvation [31,32] and inadequate intake [33–35] or high blood glucose can lead to increased BCAAs [36–38], suggesting that the increase in fecal BCAAs may be due to maternal starvation, inadequate intake or high blood glucose. Further studies on maternal illness and prenatal intake status are needed.
Benzoic acid and specific 2-oxo acids activate hepatic efflux of glutamate at OAT2
2013, Biochimica et Biophysica Acta - BiomembranesCitation Excerpt :The decrease of efflux rate over time (Fig. 2) may be caused by depletion of the cytosolic glutamate pool. Indeed, increased glutamate export by the liver has been shown to cause such a depletion and hence a decrease in urea production [4]; in this way, an increase of 2-oxo acids like ‘2-oxo-leucine’ in blood during starvation [1,29] can be translated into retention of ammonia and transfer (glutamate is made of ammonia and 2-oxo-glutarate) to other organs. In other words, stimulation of hepatic glutamate efflux by (some) natural 2-oxo acids provides physiological benefit by sparing nitrogen.
Determination of α-keto acids in rat hindquarter muscle by high-performance liquid chromatography with fluorescence detection
1988, Journal of Chromatography B: Biomedical Sciences and ApplicationsEnzymatic determination of the branched-chain α-keto acids
1987, Analytical BiochemistryCirculating Dickkopf1 Parallels Metabolic Adaptations and Predicts Disease Trajectories in Patients With COVID-19
2022, Journal of Clinical Endocrinology and Metabolism
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Supported by the Deutsche Forschungsgemeinschaft grant Scha 246/6-2.