Phenobarbital treatment enhances insulin-mediated glucose metabolism and improves lipid metabolism in the diabetic rat☆
References (52)
The role of the liver in the homeostasis of blood glucose
Curr Top Cell Regul
(1976)Mechanism of induction of hepatic drug metabolizing enzymes: Recent advances
Trends Pharmacol Sci
(1984)- et al.
Effects of 3-methylcholanthrene on oxidized nicotinamide-adenine dinucleotide phosphate-dependent dehydrogenases and selected metabolites in perfused rat liver
Biochem Pharmacol
(1980) - et al.
Effect of phenobarbitone on hepatic microsomal enzymes of the male rat
Biochem Pharmacol
(1972) Autoregulation by glucose of hepatic glucose balance: Permissive effect of insulin
Metabolism
(1981)- et al.
Regulation of hepatic glucose output by glucose in vivo
Metabolism
(1988) - et al.
Co-regulation of the mixed-function oxidation of p-nitroanisole and glucuronidation of p-nitrophenol in the perfused rat liver by carbohydrate reserves
Arch Biochem Biophys
(1981) Pharmacological implications of microsomal enzyme induction
Pharmacol Rev
(1967)- et al.
Factors regulating drug metabolism in intact hepatocytes
Pharmacol Rev
(1980) Induction of drug metabolizing enzyme system in the liver
Eur J Clin Pharmacol
(1972)
Alterations in nicotinamide and adenine nucleotide systems during mixed-function oxidation of p-nitroanisole in perfused livers from normal and phenobarbital-treated rats
Biochem J
Effects of enzyme induction therapy on glucose and drug metabolism in obese mice model of non-insulin dependent diabetes mellitus
Diabetes Res
Phenobarbital treatment enhances insulin mediated glucose metabolism in man
Res Commun Chem Pathol Pharmacol
The effect of liver microsomal enzyme inducing and inhibiting drugs on insulin mediated glucose metabolism in man
Br J Clin Pharmacol
Enzyme inducers improve insulin sensitivity in non-insulin-dependent diabetic subjects
Diabetes
Triacylglycerol metabolism in the phenobarbital-treated rat
Biochem J
Hepatic mixed function oxidase system and enzymatic glucose metabolism in rats
Diabetes Res
Antidiabetic action of vanadyl in rats independent of in-vivo insulin-receptor kinase activity
Diabetes
Independent effects of youth and poor diabetes control on responses to hypoglycemia in children
Diabetes
Epinephrine-induced insulin resistance in man
J Clin Invest
Estimation of endogenous glucose production during hyperinsulinemic-euglycemic glucose clamps. Comparison of unlabeled and labeled exogenous glucose infusates
Diabetes
Modeling error and apparent isotope discrimination confound estimation of endogenous glucose production during euglycemic glucose clamps
Diabetes
Use of a variable tracer infusion method to determine glucose turnover in humans
Am J Physiol
The reliability of rates of glucose appearance in vivo calculated from constant tracer infusions
Biochem J
Estimation of hepatic glucose output in non-steady state. The simultaneous use of 2-3H-glucose and 14C-glucose in the dog
Can J Physiol Pharmacol
Cited by (19)
Evodia alkaloids suppress gluconeogenesis and lipogenesis by activating the constitutive androstane receptor
2016, Biochimica et Biophysica Acta - Gene Regulatory MechanismsCitation Excerpt :Increasing evidence suggests that CAR also has an endobiotic function in regulating the glucose and lipid metabolism, making it a potential therapeutic target to manage metabolic disease [14–16]. Activation of CAR by phenobarbital (PB) suppresses the expression of hepatic gluconeogenic genes and hepatic glucose production in both normal and diabetes mouse models [15,17–19]. Forkhead box O1 (FoxO1) and hepatocyte nuclear factor 4α (HNF4α) function as two positive regulators of gluconeogenesis by transactivating the PEPCK and G6Pase gene promoters [20,21].
Phenobarbital reduces blood glucose and gluconeogenesis through down-regulation of phosphoenolpyruvate carboxykinase (GTP) gene expression in rats
2015, Biochemical and Biophysical Research CommunicationsCitation Excerpt :PB suppressed PEPCK gene expression would be responsible for the reduction of blood glucose. Venkatesan et al. showed that glucose production was suppressed in PB-treated diabetic rats in the insulin clamp test [21]. Because pyruvate-induced increase in blood glucose is abolished by administration of an inhibitor of PEPCK [22,23], we used pyruvate challenge test to examine the gluconeogenic activity in this study.
The constitutive androstane receptor is an anti-obesity nuclear receptor that improves in sulin sensitivity
2009, Journal of Biological ChemistryCitation Excerpt :It is tempting for us to propose that CAR may represent a novel therapeutic target to manage obesity and type 2 diabetes. Indeed, the CAR agonist phenobarbital has been shown to enhance insulin sensitivity and improve glucose and lipid metabolism in diabetic rats (36) and in diabetic patients (37, 38). Obesity is a medical problem of high prevalence.
PXR and CAR in energy metabolism
2009, Trends in Endocrinology and MetabolismCitation Excerpt :Given the fact that CAR inhibits gluconeogenesis and lipogenesis, an outstanding question is whether CAR activation offers therapeutic benefits in obese and diabetic patients, who often suffer from both hyperglycemia and hyperlipidemia. Indeed, the CAR agonist phenobarbital has been shown to enhance insulin sensitivity and improve glucose and lipid metabolism in diabetic rats [52] and in diabetic patients [53,54]. Recent findings from many laboratories have clearly suggested that PXR and CAR regulate not only drug metabolism but also energy homeostasis.
Constitutive androstane receptor activation promotes bilirubin clearance in a murine model of alcoholic liver disease
2017, Molecular Medicine Reports
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Supported in part by a grant-in-aid (946 GI-1) from the American Heart Association, Greater Los Angeles Affiliate, Inc, and by US Public Health Service Grant No. DK-39176.