Structure and structure-function relationships of sea anemone proteins that interact with the sodium channel

doi:10.1016/0041-0101(91)90205-6

Toxicon

Volume 29, Issue 9, 1991, Pages 1051-1084

https://doi.org/10.1016/0041-0101(91)90205-6 Get rights and content

Abstract

R. S. Norton. Review article—Structure and structure-function relationships of sea anemone proteins that interact with the sodium channel. Toxicon29, 1051–1084, 1991.—Sea anemones produce a series of toxic polypeptides and proteins with molecular weights in the range 3000–5000 that act by binding to specific receptor sites on the voltage-gated sodium channel of excitable tissue. This article reviews our current knowledge of the molecular basis for activity of these molecules, with particular emphasis on recent results on their receptor binding properties, the role of individual residues in activity and receptor binding, and their three-dimensional structures as determined by nuclear magnetic resonance spectroscopy. A region of these molecules that constitutes at least part of the receptor binding domain is proposed.

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Review articleStructure and structure-function relationships of sea anemone proteins that interact with the sodium channel

Abstract

J. Mol. Biol.

Life Sci.

J. Biol. Chem.

FEBS Lett.

Mar. Chem.

Biochim. biophys. Acta

J. Mol. Biol.

J. Biol. Chem.

J. Biol. Chem.

TIBS

Pestic. Biochem. Physiol.

FEBS Lett.

FEBS Lett.

Eur. J. Pharmacol.

J. Biol. Chem.

FEBS Lett.

Toxicon

Toxicon

FEBS Lett.

FEBS Lett.

FEBS. Lett.

J. Biol. Chem.

J. Pharm. Sci.

Biochem. Biophys. Res. Commun.

FEBS Lett.

FEBS Lett.

J. Biol. Chem.

Eur. J. Pharmacol.

Biochem. Biophys. Res. Commun.

Eur. J. Pharmacol.

Toxicon

J. Pharm. Sci.

Biological significance of peptides from Anemonia sulcata

Fed. Proc.

The action of a toxin from the sea anemone Anemoniae sulcata upon mammalian heart muscles

Naunyn-Schmiedeberg's Arch. Pharmacol.

Reversal of the cardiotonic and action-potential prolonging effects of DPI 201-106 by BDF 8784, a methyl-indol derivative

Br. J. Pharmacol.

Inter-genotype aggression in the solitary sea anemone Actinia tenebrosa

Mar. Biol.

Specificity of antibodies to sea anemone toxin III and immunogenicity of the pharmacological site of anemone and scorpion toxins

Eur. J. Biochem.

Habilitationsschrift

Biologically active compounds from coelenterates

Pure Appl. Chem.

Phylum Coelenterata (Cnidaria). Chemistry

Purification and characterization of four polypeptides with neurotoxic activity from Condylactis aurantiaca

Hoppe-Seyler's Z. Physiol. Chem.

Amino acid sequence of toxin III from Anemonia sulcata

Hoppe-Seyler's Z. Physiol. Chem.

The effects of anthopleurin-A on cardiac dynamics in conscious dogs

J. Pharmacol. Exp. Ther.

Calitoxin, a neurotoxic peptide from the sea anemone Calliactis parasitica: amino acid sequence and electrophysiological properties

Biochemistry

Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes

Ann. Rev. Pharmacol. Toxicol.

Structure and function of voltage-sensitive ion channels

Science

Pharmacological properties of sodium channels in cultured rat heart cells

Mol. Pharmacol.

A proton nuclear magnetic resonance study of the antihypertensive and antiviral protein BDS-I from the sea anemone Anemonia sulcata: sequential and stereospecific resonance assignment and secondary structure

Biochemistry

Determination of the three-dimensional solution structure of the antihypertensive and antiviral protein BDS-I from the sea anemone Anemonia sulcata: a study using nuclear magnetic resonance and hybrid distance geometry-dynamical simulated annealing

Biochemistry

The clownfish sea anemones: Stichodactylidae (Coelenterata, Actiniaria) and other sea anemones symbiotic with pomacentrid fishes

Trans. Am. Philos. Soc.

Review article
Structure and structure-function relationships of sea anemone proteins that interact with the sodium channel