PaperGeneration of reactive oxygen species and activity of platelet-activating factor acetylhydrolase in human monocyte-derived macrophages
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2018, SynergyCitation Excerpt :Determination of 8-Isop following LPS stimulation as measure of total antioxidant activity of 1,8-cineole (10−6–10−5 M) revealed strong dose-dependent inhibitory, antioxidant effects in the range of 50–80%. In an arteriosclerosis model, FCS (10%) was also shown to stimulate O2− -radicals and, in particular, hyperlipidaemic serum stimulated the differentiation of monocytes into macrophages [26]. Using this approach, we found evidence for the first time that 1,8-cineole at very low concentrations (10−10 M) only controlled H2O2 production alone, and at low concentration (10−6 M) SOD and H2O2, but not O2−, were inhibited at a medium concentration of (6 × 10−6 M, 0.9 μg/ml) together with all of the other measured parameters.
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