[47] Ebselen: A glutathione peroxidase mimic
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2012, Clinica Chimica ActaCitation Excerpt :Ebselen, 2-phenyl-1,2-benzisoselenazol-3(2 H)one (Fig. 1B), catalyzes thiol-dependent reduction of peroxides by a non-radical mechanism [12,13]. Although earlier literature suggested that ebselen has properties such as free radical quenching [12], this activity was subsequently shown to have little effect [14]. Sequential reduction of ebselen by glutathione produces a selenol which is the direct reductant for the peroxides [13].
Copyright © 1994 Published by Elsevier Inc.