Cell
Volume 35, Issue 3, Part 2, December 1983, Pages 603-610
Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor
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EGFR signaling activates intestinal stem cells by promoting mitochondrial biogenesis and β-oxidation
2022, Current BiologyCitation Excerpt :Early studies of proliferation in cultured cells show that growth factors trigger a stepwise temporal program of gene expression that culminates in DNA replication and, later, mitosis.55 Transcriptional activation of primary responder (“immediate early”) genes relies on pre-existing receptors and transcriptional regulators and can occur without de novo protein synthesis, whereas secondary responder (“delayed early”) genes require new expression of additional transcription factors.55–58 To assess this growth factor stimulation process in a physiological context, we assayed ISC transcriptomes after 8 and 24 h of sSpi induction.
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