Cell
Volume 49, Issue 3, 8 May 1987, Pages 347-356
ArticleCorrect integration of retroviral DNA in vitro
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2019, Journal of Biological ChemistryCitation Excerpt :RT converts retroviral RNA into a single molecule of linear DNA containing a copy of the viral long terminal repeat (LTR) at each end (Figs. 1 and 2) (reviewed in Ref. 4). The linear DNA, comprised of U3 and U5 terminal sequences in respective upstream and downstream LTRs, is the substrate for IN-mediated viral DNA insertion into chromosomal DNA (5–7). Four classes of antiretroviral drugs, nucleoside RT inhibitors (NRTIs), nonnucleoside RT inhibitors (NNRTIs), PR inhibitors (PIs), and IN strand transfer inhibitors (INSTIs) have in recent years comprised frontline cART formulations (8).
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