Cell
Volume 61, Issue 3, 4 May 1990, Pages 505-514
ArticleModular structure of a chicken lysozyme silencer: Involvement of an unusual thyroid hormone receptor binding site
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TRF2 cooperates with CTCF for controlling the oncomiR-193b-3p in colorectal cancer
2022, Cancer LettersCitation Excerpt :The mechanism through which CTCF takes part in control of gene expression has been long studied in the literature. This zinc-finger protein that was originally identified in a context of gene silencing and repression [53,54], was subsequently shown to be involved in a large array of transcriptional mechanisms, including gene activation [55], insulation [56–59], imprinting [60–62] and X chromosome inactivation [63–65]. Notably, these multiple (and sometimes diametrically opposed) regulatory activities of CTCF have been found to not directly depend on its transcriptional activity but rather on the capability of this protein to affect the global organization of chromatin architecture.
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