Review articlePeptidergic pathway in human skin and rat peritoneal mast cell activation
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Cited by (129)
Mast cell anaphylatoxin receptor expression can enhance IgE-dependent skin inflammation in mice
2013, Journal of Allergy and Clinical ImmunologyCitation Excerpt :Many studies have reported the expression of C3aR and C5aR on mast cell populations,11,13,35,36 and a blocking antibody against C5aR can reduce C5a-mediated degranulation of human skin mast cells in vitro, which is evidence that C5a can directly activate human skin mast cells through C5aR.11 However, other groups have reported that C3a and C5a, which are cationic, can bind nonspecifically to rat peritoneal mast cells through electrostatic interactions with anionic heparin-proteoglycan on the mast cell surface.37-39 C3a- or C5a-induced ear-swelling responses were significantly reduced in mast cell–engrafted KitW-sh/W-sh mice, the skin mast cells of which lacked C3aR or C5aR, respectively, confirming that the binding of each anaphylatoxin to its specific receptors on skin mast cells can markedly enhance the skin-swelling response induced by that anaphylatoxin in vivo.
Relevance of mast cell-nerve interactions in intestinal nociception
2012, Biochimica et Biophysica Acta - Molecular Basis of DiseaseCitation Excerpt :In human, seven Mrg receptors are expressed; MrgX1-MrgX7, while in rodents, the family of Mrg receptors can be further subdivided in MrgD and three subfamilies; MrgA, MrgB and MrgC based on homology analysis [113]. Several ligands such as; BAM peptides, neuropeptide FF (NPFF), dynorphin 14 and γ2-melanocyte-stimulating hormone are capable of activating Mrg-receptors [64,87,90,106,114,116,131,132,139,152,186,221]. Peptides known to activate the MrgC receptor have been shown to elicit pain-like behavior when administrated to rats [82].
G protein coupled receptor specificity for C3a and compound 48/80-induced degranulation in human mast cells: Roles of Mas-related genes MrgX1 and MrgX2
2011, European Journal of PharmacologyCitation Excerpt :Furthermore, MrgX1 and MrgX2 are expressed in human cord blood-derived mast cells and compound 48/80 activates transfected cells expressing MrgX2 but not MrgX1 (Tatemoto et al., 2006). Previous studies indicated that C3a could activate both human skin mast cells and rat peritoneal mast cells via a pathway similar to that mediated via compound 48/80 (el-Lati et al., 1994; Mousli et al., 1992; 1994). This raises the intriguing possibility that C3a-induced mast cell degranulation could involve both C3a receptor and MrgX2.
Mast Cells and Basophils
2023, Inflammatory Mechanisms in Allergic Diseases