Genetic variants of human serum cholinesterase influence metabolism of the muscle relaxant succinylcholine
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2019, Chemico-Biological InteractionsCitation Excerpt :Usually, treatment of OP poisoning consists of supportive care and specific post exposure therapy e.g. atropine and oximes e.g. 2-PAM [5,6], which often fail to prevent morbidity or death because they do not efficiently pass the blood-brain-barrier [7]. To date, the stoichiometric tetrameric human plasma enzyme, butyrylcholinesterase (HuBChE)(EC3.1.1.8, pseudo-cholinesterase, nonspecific cholinesterase) [8], has been the leading pretreatment candidate against OP exposure [9–11]. Due to limited availability and cost, focus on an efficacious OP countermeasure has switched to the development of recombinant (r) HuBChE [12–16] or alternate catalytic bioscavengers [17–19].
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Copyright © 1990 Published by Elsevier Inc.