Normal lymphocyte responsiveness to lectins but impaired sensitivity to in vitro glucocorticoids in major depression
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2017, Pharmacological ReportsCitation Excerpt :GRs are widely distributed in the organism and affect many important physiological functions of the human body in response to glucocorticosteroids, such as stress reactions, immune and inflammatory processes, sleep or growth and reproduction [94]. Patients with major depressive disorder might have reduced GR sensitivity [96]. The functional polymorphism of GRs might also play a pivotal role in depression and antidepressant treatment [97].
Lower Methylation of Glucocorticoid Receptor Gene Promoter 1F in Peripheral Blood of Veterans with Posttraumatic Stress Disorder
2015, Biological PsychiatryCitation Excerpt :The GR resistance associated with lower glucocorticoid feedback sensitivity in depressed patients is apparent in reduced GR function in leukocytes reflected by decreased nuclear translocation after DEX exposure (38) and diminished DEX-induced inhibition of mitogen-associated PBMC proliferation (39). Glucocorticoid resistance in peripheral immune cells seen in depression correlates with glucocorticoid resistance in the DEX suppression test (40). The obvious contrast between these findings and the evidence for enhanced GR sensitivity in PTSD is particularly interesting considering the frequent comorbidity of depression and PTSD.
Icaritin opposes the development of social aversion after defeat stress via increases of GR mRNA and BDNF mRNA in mice
2013, Behavioural Brain ResearchCitation Excerpt :Impaired glucocorticoid sensitivity has been observed in social defeat models and depressed patients [19,20]. Studies on immune cells from peripheral blood have shown that the capacity of glucocorticoids to inhibit proliferation of PBMCs in response to polyclonal mitogens is impaired in depressed patients [21–23]. In this study we demonstrated that corticosterone concentrations that reduced viability of spleen cells from control mice had little effect on the viability of cells from social defeated mice.
The glucocorticoid receptor: Pivot of depression and of antidepressant treatment?
2011, PsychoneuroendocrinologyDifferential modulation of cytokine production in major depressive disorder by cortisol and dexamethasone
2008, European Neuropsychopharmacology