A comparison of the mutagenicity of mainstream cigarette smoke condensates from a representative sample of the U.S. cigarette market with a Kentucky reference cigarette (K1R4F)☆
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Cited by (55)
Development, qualification, validation and application of the Ames test using a VITROCELL<sup>®</sup> VC10<sup>®</sup> smoke exposure system
2018, Toxicology ReportsCitation Excerpt :In addition, the VITROCELL® VC10® system has been shown to be a robust and reproducible in vitro method through an inter-machine comparison of tobacco smoke particle deposition using six independent smoke exposure systems [44]. Furthermore, the Ames test is widely used in the evaluation of mutagenicity in vitro including assessments of cigarette smoke [45,58–69]. However, the World Health Organisation does not support the use of machine smoke emission data to support claims of reduced exposure or reduced risk to humans [70].
The mutagenic assessment of an electronic-cigarette and reference cigarette smoke using the Ames assay in strains TA98 and TA100
2016, Mutation Research - Genetic Toxicology and Environmental MutagenesisCitation Excerpt :These guidelines ensure the uniformity and robustness of data submitted to regulatory agencies for registration or acceptance of many chemicals. The Ames assay has been used for the assessment of tobacco smoke using both TPM (total particulate matter) and whole aerosol approaches, and has been shown to be mutagenic in many strains, including TA98, TA100, TA1537, YG1024, YG1042, and TA104 (+/−S9) [3–12]. In terms of cigarette smoke assessment, the Ames assay has been extensively characterised, developed and deployed, and there is a wealth of historical data in which existing and modified tobacco products and even new categories, such as electronic-cigarettes (e-cigarettes), can be assessed against.
The mutagenic assessment of mainstream cigarette smoke using the Ames assay: A multi-strain approach
2015, Mutation Research - Genetic Toxicology and Environmental MutagenesisCitation Excerpt :Based on the available literature and data, the following strains may be employed in a regulatory-style format for the assessment of the mutagenic potential of cigarette smoke or alternative aerosol-based tobacco products: TA98 and TA100 are important to maintain in a smoke aerosol testing strategy as there is a great deal of historical data, especially from a TPM perspective [18–20,26,27]. However, the increased sensitivity of YG1024 and YG1042 could prove useful when comparing between tobacco products, especially aerosol based.
A method for assessment of the genotoxicity of mainstream cigarette-smoke by use of the bacterial reverse-mutation assay and an aerosol-based exposure system
2014, Mutation Research - Genetic Toxicology and Environmental MutagenesisMainstream smoke chemistry analysis of samples from the 2009 US cigarette market
2012, Regulatory Toxicology and PharmacologyCitation Excerpt :Over the years, R.J. Reynolds Tobacco Company has conducted surveys of the US cigarette marketplace in order to provide a snapshot of the range of market yields for selected mainstream smoke constituents and mutagenicity. In the past, these surveys were conducted using the Cambridge Filter Method (CFM) for smoking the cigarettes evaluated (Steele et al., 1995; Swauger et al., 1997, 2002; deBethizy, 1998; Chepiga et al., 2000). With the onset of interest in smoking regimens more intensive than the CFM, it was decided to survey the US marketplace using the Health Canada smoking regimen of a 55 cc puff taken every 30 s for a 2 s duration with 100% of the ventilation holes blocked.
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Presented in part at the 30th Annual Meeting of the Society of Toxicology, Dallas, Texas, 1991.