Trends in Pharmacological Sciences
Volume 9, Issue 8, August 1988, Pages 299-304
Basic carboxypeptidases: regulators of peptide hormone activity
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Identification and characterization of a carboxypeptidase N1 from red lip mullet (Liza haematocheila); revealing its immune relevance
2019, Fish and Shellfish ImmunologyCarboxypeptidase M is a positive allosteric modulator of the kinin B1 receptor
2013, Journal of Biological ChemistryCitation Excerpt :For example, BK and KD released from kininogen are B2R agonists, and carboxypeptidase-mediated removal of their C-terminal Arg residue inactivates them as B2R agonists while simultaneously generating B1R agonists (6, 11, 14). Although B1R agonists can potentially be produced by several carboxypeptidases in various cellular and subcellular locations (6, 11, 14), if the site of generation is not close to the receptor, the agonist concentration will be reduced by diffusion and short peptide half-life due to exposure to cellular and blood proteases and filtration by the kidney. Thus, peptide agonist generation in close proximity to its corresponding receptor is most likely to lead to a meaningful cellular response.
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Copyright © 1988 Published by Elsevier Ltd.