Trends in Pharmacological Sciences
Data normalization before statistical analysis: keeping the horse before the cart
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2018, International Journal of Biochemistry and Cell BiologyCitation Excerpt :Statistical comparison of cell death, cellular ATP content and MMP EC50 values were performed using Student’s t-test with Welch correction, with cell line as IV and logEC50 as DV. Statistical comparisons were performed upon logEC50 values as they follow a normal distribution (Hancock et al., 1988). To determine whether NNMT was capable of N-methylating 4-PP, we incubated hNNMT with 1 mM 4-PP prepared in DMSO (5% v/v final concentration, approximately 700 mM) (Fig. 2).