Trends in Pharmacological Sciences
ViewpointThe role of membrane biophysical properties in the regulation of protein kinase C activity
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The scientific adventures of Richard Epand
2023, Biophysical ChemistryMethods of reconstitution to investigate membrane protein function
2018, MethodsCitation Excerpt :Rigaud et al., developed the system further and introduced a number of “guidelines” for the process of protein reconstitution into liposomes. This inspired the use of PLs to investigate the function of a huge range of IMPs including ion channels and receptors [82–91], enzymes [92–96], and transporters [8,97–109]. Different sizes of liposomes can be made and those with diameter φ < 100 nm are loosely defined as small unilamellar vesicles (SUVs), while large unilamellar vesicles (LUVs) have diameters φ = 100–300 nm [110,111].
Membrane curvature modulation of protein activity determined by NMR
2015, Biochimica et Biophysica Acta - BiomembranesCitation Excerpt :The most direct control of enzyme activity by membrane intrinsic curvature has been shown for CTP: phosphocholine cytidylyltransferase [10,11] and rhodopsin [12–14]. There are also other enzymes, such as protein kinase C, whose activity is affected by binding to membranes with different curvature properties [15,16]. However, in the case of protein kinase C the correlation appears to be mediated through a curvature modulation of membrane interfacial polarity [17].
Cholesterol modulates function of connexin 43 gap junction channel via PKC pathway in H9c2 cells
2014, Biochimica et Biophysica Acta - BiomembranesCitation Excerpt :Cholesterol has been shown to affect membrane protein structure and function both by binding directly to specific binding sites on the protein and by changing various biophysical properties of the bilayer [25]. It is known that PKC activity is dependent on the nature of the membrane environment [26–28]. In their series studies [11,27–29], Zidovetzki et al. demonstrated that PKC activity can be increased by lipophilic compounds that can destabilize bilayers by increasing their propensity to adopt the nonbilayer lipid phase.