Trends in Neurosciences
Volume 15, Issue 10, 1992, Pages 396-402
ReviewModulation of pH by neuronal activity
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Circadian clock organization in the retina: From clock components to rod and cone pathways and visual function
2023, Progress in Retinal and Eye ResearchCitation Excerpt :Although all living tissue produces acid due to metabolic activity, it has been widely accepted that the acid/base ratio, as represented by pH, is strictly regulated to maintain normal function. In the nervous system, however, evidence has shown that neuronal activity can result in shifts in pH that are large enough to influence enzyme and channel functions (Chesler and Kaila, 1992; more recent refs). In the retina, the pH of the extracellular space varies with light stimulation and light/dark adaptation.
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