Review
The neostriatal mosaic: multiple levels of compartmental organization

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Abstract

The striatum, which is the major component of the basal ganglia, displays a complex mosaic organization of neurochemical systems that are related to its neuroanatomical connections. This mosaic organization reflects multiple levels of functional compartments. The first level is determined by the segregation of two major striatal output systems, one to the globus pallidus (external segment) and the other to the entopeduncular nucleus and substantia nigra. The second level segregates the cortical outputs of sublaminae of layer V between the patch and matrix compartments of the striatum, which project to the dopaminergic and GABAergic neurons in the substantia nigra, respectively. The third level is related to the topography of cortical inputs by which regions of the striatum may be functionally defined on the basis of the cortical areas with which they are connected. Neurochemical markers display complex mosaic patterns in the striatum that, when examined in the context of the multi-level compartmental organization of the striatum, reveal the highly organized manner by which the striatum processes cortical information.

References (69)

  • S.T. Kitai et al.

    Brain Res.

    (1976)
  • J. Jimenez-Castellanos et al.

    Neuroscience

    (1987)
  • H. Kita et al.

    Brain Res.

    (1988)
  • G. Chevalier et al.

    Brain Res.

    (1985)
  • C.R. Gerfen et al.

    Brain Res.

    (1988)
  • H. Nakanishi et al.

    Brain Res.

    (1987)
  • I.J. Mitchell

    Neuroscience

    (1989)
  • J.M. Deniau et al.

    Brain Res.

    (1985)
  • R.L. Albin et al.

    Trends Neurosci.

    (1989)
  • F. Petitet et al.

    Eur. J. Pharmacol.

    (1991)
  • C.R. Gerfen

    Brain Res.

    (1991)
  • J. Jimenez-Castellanos et al.

    Neuroscience

    (1989)
  • M. Herkenham et al.

    Neuroscience

    (1984)
  • J.P. Bolam et al.

    Neuroscience

    (1988)
  • C.W.J. Ragsdale et al.

    Brain Res.

    (1981)
  • J.P. Donoghue et al.

    Brain Res.

    (1986)
  • A.M. Graybiel et al.

    Neuroscience

    (1981)
  • F. Ferino et al.

    Brain Res.

    (1987)
  • G.F. Alheid et al.

    Neuroscience

    (1988)
  • E.A. Grove et al.

    Brain Res.

    (1986)
  • W.J.H. Nauta et al.

    Neuroscience

    (1978)
  • E.H. Yeterian et al.

    Brain Res.

    (1978)
  • J.M. Kemp et al.

    Phil. Trans. R. Soc. London Ser. B

    (1971)
  • C.J. Wilson et al.

    J. Comp. Neurol.

    (1980)
  • C.R. Gerfen et al.

    J. Comp. Neurol.

    (1982)
  • C.R. Gerfen et al.

    J. Neurosci.

    (1987)
  • Y. Kawaguchi et al.

    J. Neurosci.

    (1990)
  • R.M. Beckstead et al.

    J. Comp. Neurol.

    (1985)
  • Y. Smith et al.

    J. Comp. Neurol.

    (1990)
  • Y. Smith et al.

    Eur. J. Neurosci.

    (1990)
  • H. Kita et al.

    J. Comp. Neurol.

    (1987)
  • C. Le Moine
  • C.R. Gerfen

    Science

    (1990)
  • C.R. Gerfen et al.

    J. Neurosci.

    (1991)
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