Anti-inflammatory and immunosuppressive properties of the bis-benzylisoquinolines: In vitro comparisons of tetrandrine and berbamine

doi:10.1016/0192-0561(89)90086-6

International Journal of Immunopharmacology

Volume 11, Issue 4, 1989, Pages 395-401

International Journa...

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Abstract

Tetrandrine and berbamine are two naturally occuring analogues with a bis-benzylisoquinoline structure. Comparative in vitro studies show that tetrandrine has significantly greater suppressive effects on adherence, locomotion and ³H-deoxyglucose uptake of neutrophils, as well as the mitogen-induced lymphocyte responses and mixed lymphocyte reactions. Also, tetrandrine displayed anti-oxidant activity while berbamine did not. By contrast, berbamine demonstrated a significantly greater capacity for inhibition of NK cell cytotoxicity.

These results show that tetrandrine is superior to berbamine in most aspects of anti-inflammatory and immunosuppressive activity. Since these two alkaloids differ by only one substitution in the side chain of one of the benzene rings, these findings may provide further insight into structure — activity relationships and clues to the synthesis and development of active analogues of this promising class of drugs for the treatment of chronic inflammatory diseases.

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International Journal of Immunopharmacology

Abstract

References (19)

Inhibitory effects of tetrandrine on human neutrophil and monocyte adherence

Immun. Lett.

Development of a microassay for ³H-deoxyglucose uptake by human neutrophils and monocytes

J. Immun. Meth.

Development of a microassay technique for neutrophil adherence

J. Immun. Meth.

Observations of the effect of tetradrine on experimental silicosis of rats

Exotoxicol. envir. Safety

Two pharmacological traditions: notes from experience

Ann. Rev. Pharmac. Toxicol.

As cited in: Returning to nature for medicinal marvels

Curr. Cont.

The effect of antimalarial drugs on natural killer cells in-vitro

Parasite Immun.

Depression of human polymorphonuclear leukocyte function by antimalarial drugs

Immunology

Cited by (71)

pH-sensitive HPMCP-chitosan nanoparticles containing 5-aminosalicylic acid and berberine for oral colon delivery in a rat model of ulcerative colitis

Promising trypanocidal heterocyclic compounds of natural origin and their synthetic analogs

C-Jun NH<inf>2</inf>-terminal kinase-induced proteasomal degradation of c-FLIP<inf>L/S</inf> and Bcl<inf>2</inf> sensitize prostate cancer cells to Fas- and mitochondria-mediated apoptosis by tetrandrine

A rapid and sensitive LC-MS/MS assay for the determination of berbamine in rat plasma with application to preclinical pharmacokinetic study

Effects of berberine gelatin on recurrent aphthous stomatitis: A randomized, placebo-controlled, double-blind trial in a Chinese cohort

Combination of Tetrandrine with cisplatin enhances cytotoxicity through growth suppression and apoptosis in ovarian cancer in vitro and in vivo