ArticleVisualization of cholecystokinin receptors on a subset of human monocytes and in rat spleen
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The critical role of CCK in the regulation of food intake and diet-induced obesity
2021, PeptidesCitation Excerpt :Supplementary Table 2 summarizes the identification process of CCK receptors in different species. CCK2R are generally found in the mid-glandular and fundic mucosa of the stomach as well as the fundic circular muscle [99], the colon [100], pancreas [101], monocytes [102], nodose ganglia [103,104], and in regions throughout the brain [94,95,98,105–107] including the anterior nucleus accumbens [108], amygdala, habenula, ventral pallidum, thalamus, spinal cord [107], cortex, hippocampus, and the olfactory bulb [98,106,107]. Among its many roles, activation of CCK2R in the anterior nucleus accumbens inhibits dopamine release [108] and has a role in motivated behavior [109].
Cholecystokinin protects mouse liver against ischemia and reperfusion injury
2017, International ImmunopharmacologyCitation Excerpt :A clinical trial demonstrated that CCK levels stimulated by intestinal nutrient were elevated in septic and critically ill patients [25]. In our study, similar to the result in humans, CCK levels in blood and liver presented an increase in the entire process of hepatic 24 h reperfusion and peaked at 6 h. Additionally, it has been reported that CCK-AR is not solely expressed on monocytes [26], but also highly expressed on peritoneal macrophages and upregulated under the stimulus of LPS and/or high CCK concentrations [17]. Moreover, mRNA of both CCK-AR and CCK-BR are increased in pulmonary interstitial macrophages by LPS stimulation [27].
Regulation of nutrition-associated receptors in blood monocytes of normal weight and obese humans
2015, PeptidesCitation Excerpt :Neurotensin plays a proinflammatory role in acute intestinal inflammation, whereas in chronic intestinal inflammation it may also promote mucosal healing [16]. The distribution of these nutrition-associated receptors has been investigated to some extend in the human immune system [5,7,16–22]. However, the existence of functional surface receptors in immune cells was often demonstrated using microarray data [23], ligand binding experiments [16] or ligand stimulation, without validation at the mRNA and protein level by a reverse transcription or real-time PCR and western blotting, respectively.
The investigation of membrane binding by amphibian peptide agonists of CCK2R using <sup>31</sup>P and <sup>2</sup>H solid-state NMR
2014, PeptidesCitation Excerpt :CCK2 receptors are predominantly located throughout the brain, CNS and in specific parts of the gastrointestinal tract. They also are present on some lymphocytes and splenocytes (e.g. as monocytes, T-cells, and lymphoblasts [31–33,39,43,44].1 The simplest mechanistic pathway that can mediate the binding of, for example, a peptide hormone (such as adrenaline and melatonin) to transmembrane receptors involves a lock-and-key mechanism, where the hormone binds directly to the transmembrane receptor from the extracellular fluid, triggering a cellular response via a secondary messenger pathway [31–33,39].
Gastrointestinal Peptides: Gastrin, Cholecystokinin, Somatostatin, and Ghrelin. Gastrin, Cholecystokinin, Somatostatin, and Ghrelin
2012, Physiology of the Gastrointestinal Tract, Two Volume SetGastrointestinal Peptides: Gastrin, Cholecystokinin, Somatostatin, and Ghrelin
2012, Physiology of the Gastrointestinal Tract
- 1
Present address: Department of Pharmacology, University of Milan, Via Vanvitelli 32, 20129 Milano, Italy.
- 2
Present address: Department of Internal Medicine, University of Innsbruck, A-6020 Innsbruck, Austria.