Behavioral effects of α-MSH and MCH after central administration in the female rat

doi:10.1016/0196-9781(95)02092-6

Peptides

Volume 17, Issue 1, 1996, Pages 171-177

https://doi.org/10.1016/0196-9781(95)02092-6 Get rights and content

Abstract

The behavioral effects of α-MSH, MCH, and α-MSH + MCH were investigated in the ventromedial nucleus (VMN) and medial preoptic area (MPOA) (bilateral, 100 ng in 0.5 μl). Infusion of α-MSH into the VMN increased aggressive behavior; in the MPOA it reduced exploration and increased anxiety. In both areas it stimulated sexual behavior. MCH also stimulated sexual behavior in the MPOA and VMN and had an anxiogenic effect in the MPOA. The effect of α-MSH on aggression and exploration was antagonized by MCH. When given together, the two peptides were mutually antagonistic on anxiety. This study indicates that MCH has central nervous system effects and may be a partial α-MSH agonist.

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ArticleBehavioral effects of α-MSH and MCH after central administration in the female rat

Abstract

Physiol. Behav.

Trends Endocrinol. Metab.

Peptides

Neurosci. Biobehav. Rev.

Physiol. Behav.

Peptides

Brain Res.

Brain Res.

Neurosci. Biobehav. Rev.

Peptides

Peptides

Brain Res.

J. Neurosci. Methods

Gen. Comp. Endocrinol.

Neuroscience

Peptides

Brain Res. Bull.

Salmonid melanin-concentrating hormone inhibits corticotrophin release

J. Endocrinol.

Peptides and behaviour; Proposed mechanisms by which α-MSH induces excessive grooming behaviour

Comun. Biol.

Effect of serotonergic lesions on “anxious” behaviour measured in the elevated plus-maze test in the rat

Psychopharmacology (Berlin)

The melanotropins: Chemistry, physiology and mechanisms of action

Morphofunctional studies on the neurons producing melanin-concentrating hormone

Ann. NY Acad. Sci.

Article
Behavioral effects of α-MSH and MCH after central administration in the female rat