Induction of hepatic cytochrome P4502E1 in rats by acetylsalicylic acid or sodium salicylate
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Modulation of trichloroethylene in vitro metabolism by different drugs in rats
2013, Toxicology in VitroCitation Excerpt :Zieliñska-Psuja et al., 1999) reported such an induction during an in vivo treatment by this drug. This was also observed by (Damme et al., 1996) and (Favari et al., 1997), confirming that acetylsalicylic acid can act as an inducer of CYP450. Further investigations are still needed to elucidate the mechanism of the observed inhibition in hepatocytes.
Enhancement of the predicted drug hepatotoxicity in gel entrapped hepatocytes within polysulfone-g-poly (ethylene glycol) modified hollow fiber
2010, Toxicology and Applied PharmacologyCitation Excerpt :Except for amiodarone, hepatocytes in cylindrical gel were less sensitive to the hepatotoxic drugs than those in PSf-g-PEG hollow fiber (Fig. 4). The lower sensitivity in absence of hollow fibers could be due to their much lower CYP 2E1 and 3A activity which respectively mediated the hepatotoxicity of acetaminophen/salicylate (Damme et al., 1996; Cheung et al., 2005) and clozapine (Lu et al., 2008). As the enzymes of CYP 450 have been suggested to be involved in most drug hepatotoxicity including tetracycline, azathioprine, rifampicin and chloroquine (Meng, 2010), it was highly possible that the underestimated toxicity of these drugs was caused by the low CYP 450 activity of hepatocytes in the culture without hollow fibers.
Electron paramagnetic resonance decay constant and oxidative stresses in liver microsomes of the selenium-deficient rat
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2005, Prostaglandins Leukotrienes and Essential Fatty AcidsMetabolic interactions between acetylsalicylic acid and benzene
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