Review
Interactions of 1,25-dihydroxyvitamin D3 and the immune system

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Abstract

A series of recent discoveries indicate that the hormonal form of vitamin D3, namely, 1,25(OH)2D3 plays a role in the regulation of the immune system. Cells of the monocyte/macrophage lineage possess receptors for 1,25(OH)2D3 regardless of their activation stage; cells of the lymphoid lineage also express these receptors but only at certain stages of their differentiaion pathway and upon activation. Further, 1,25(OH)2D3 promotes the differentation of monocyte precursors towards monocyte/macrophages and enhances monocyte function in antigen presentation. In addition 1,25(OH)2D3 is a potent inhibitor of interleukin-2 (IL-2) and suppresses effector functions of both T and B lymphocytes via IL-2-dependent as well as via IL-2-independent mechanisms. The theoretical and clinical implications of these discoveries are discussed.

References (61)

  • A.H. Lichtman et al.

    Blood

    (1983)
  • S.C. Manolagas et al.

    J. Biol. Chem.

    (1980)
  • S.J. Marx et al.

    J. Biol. Chem.

    (1974)
  • C. Miyaura et al.

    Biochem. Biophys. Res. Commun.

    (1981)
  • D.M. Provvedini et al.

    Biochem. Biophys. Res. Commun.

    (1984)
  • A. Ravid et al.

    Biochem. Biophys. Res. Commun.

    (1984)
  • H. Tanaka et al.

    Biochem. Biophys. Res. Commun.

    (1983)
  • C.D. Tsoukas et al.

    Immunol. Today

    (1984)
  • E. Abe et al.
  • E. Abe et al.
  • E.P. Amento et al.

    J. Clin. Invest.

    (1984)
  • R. Baron et al.
  • Z. Bar-Shavit et al.

    Calcif. Tissue Int.

    (1981)
  • A.K. Bhalla et al.

    J. Clin. Endocrinol. Metab.

    (1983)
  • A.K. Bhalla et al.

    J. Immunol.

    (1984)
  • E. Bonucci

    Clin. Orthop. Relat. Res.

    (1981)
  • N.A. Breslau et al.

    Ann. Intern. Med.

    (1984)
  • T.R. Cupps et al.

    Immunol. Rev.

    (1982)
  • R.C. Dodd et al.
  • H.F. DeLuca

    Nutr. Rev.

    (1979)
  • H.F. DeLuca

    J. Clin. Endocrinol. Metab.

    (1980)
  • D.L. Droege et al.

    Transplant. Rev.

    (1975)
  • M.D. Fallon et al.

    Lab. Invest.

    (1983)
  • T. Fujita et al.

    Miner. Electrolyte Metabol.

    (1984)
  • C.J. Grossman

    Science

    (1985)
  • M.R. Haussler et al.

    N. Engl. J. Med.

    (1977)
  • A.J. Kahn et al.

    Science

    (1978)
  • L. Key et al.

    N. Engl. J. Med.

    (1984)
  • H.P. Koeffler et al.

    Biochem. Biophys. Res. Commun.

    (1985)
  • J.M. Lemire et al.

    J. Clin. Invest.

    (1984)
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