Research paperCytochromes CYP1A1 and CYP1B1 in the rat mammary gland: Cell-specific expression and regulation by polycyclic aromatic hydrocarbons and hormones
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T-2 toxin upregulates the expression of human cytochrome P450 1A1 (CYP1A1) by enhancing NRF1 and Sp1 interaction
2019, Toxicology LettersCitation Excerpt :Many cis-acting elements that bind to the promoter region of CYP1A1 have been identified, including AhR/ARNT, Sp1, nuclear factor-Y/α-actinin-4 (NF-Y/ACTN4), hypoxia-inducible factor-1α (HIF1α), pregame X receptor (PXR) and CCAAT/enhancer binding protein α (C/EBPα) (Fallone et al., 2005; Jie et al., 2008; Kim et al., 2015; Kobayashi et al., 1996; Poch et al., 2004; Shimoyama et al., 2014). A previous report showed that AhR binds to XRE and regulates the induction of CYP1A1 expression in response to TCDD (Christou et al., 1995; Nishimura et al., 2005). These findings indicate that the transcriptional network that regulates the transcription of CYP1A1 is complicated and diverse.
Cancer chemoprevention revisited: Cytochrome P450 family 1B1 as a target in the tumor and the microenvironment
2018, Cancer Treatment ReviewsCitation Excerpt :In the murine mammary gland CYP1A1 and CYP1B1 are expressed at low levels in physiological conditions, with CYP1A1 primarily localized in the epithelial cells and CYP1B1 in fibroblasts. The expression of epithelial CYP1A1 and fibroblast CYP1B1 could be further induced by administration of BaP or TCDD [197,198]. The analysis of normal human breast tissues also demonstrated that fibroblasts constitutively express CYP1B1 (but not CYP1A1 and CYP1A2) and that these levels can be further induced by TCDD [199].
Murine precision-cut lung slices exhibit acute responses following exposure to gasoline direct injection engine emissions
2016, Science of the Total EnvironmentCYP1B1 and hormone-induced cancer
2012, Cancer LettersCitation Excerpt :Additionally, we hypothesize a role for γ-synuclein (SNCG), a neuronal protein required for efficient transcriptional activation of ERα [34], in CYP1B1-mediated hormonal carcinogenesis. CYP1B1 activity is regulated via several factors including aryl hydrocarbon receptor (AhR), the AhR/AhR nuclear translocator (ARNT) complex, Sp1 transcription factors, epigenetic regulation (e.g., CYP1B1 promoter methylation), endogenous oestrogen levels, ERs and BRCA-1 activity [35–37]. In non-cancerous tissues, CYP1B1 is transcriptionally activated when compounds including PAHs or dioxins bind to the AhR complex [consisting of AhR, Hsp90, X-associated protein 2 (XAP2) and p23 proteins] in the cytosol [24,38].