Anticancer and antioxidant activity of synthetic chalcones and related compounds

doi:10.1016/0304-3835(95)03945-S

Cancer Letters

Volume 97, Issue 1, 20 October 1995, Pages 33-37

https://doi.org/10.1016/0304-3835(95)03945-S Get rights and content

Abstract

Nineteen synthetic chalcones and ten structurally related compounds were investigated for their cytotoxic, tumour reducing and antioxidant activities. Methyl and hydroxy substituted chalcones were found to be cytotoxic in vitro whereas only hydroxy substituted chalcones could reduce ascites tumour in animals. Although most of the compounds analysed showed antioxidant activity, hydroxy and methyl substituted compounds were found to be the most potent antioxidants.

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Cancer Letters

Abstract

References (16)

Screening of 11 ferns of cytotoxic and antitumour potential with special reference to Pityrogramma calomelanos

J. Ethnopharmacol.

Possible anticancer activity of turmeric

Cancer Lett.

Superoxide dismutase, an enzymatic function for erythrocuprein

J. Biol. Chem.

Flavanoid front exudates from two Jamaican ferns, Pityrogramma tartarea and P. calomelanos

Phytochemistry

The Chemistry of Chalcones and Related Compounds

Anti-inflammatory, analgesic and anti-pyretic activities of 3-(4-(3-(4-dimethylaminophenyl)-1-oxo-2-propenyl) phenyl)sydnone

Indian Drugs

Anti-mutagenic chalcones: antagonising the mutagenicity of benzo(a)pyrene in Salmonella typhymurium

Biochem. Biophys. Res. Commun.

Tumour reducing and antioxidant activities of Sydnone-substituted chalcones

J. Clin. Biochem. Nutr.

Cited by (0)