Selective potentiation of GABA-mediated Cl− current by lanthanum ion in subtypes of cloned GABAA receptors
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Functional impact of serial deletions at the C-terminus of the human GABAρ1 receptor
2010, Biochimica et Biophysica Acta - BiomembranesCitation Excerpt :This is consistent with the presumed mechanism of action of both molecules, since TPMPA is known to compete for the agonist binding site [19,23,24], and zinc binds to residue H156 present in the extracellular domain of the receptor [10], and both sites were unaffected in the functional deletions. La3+ acts on GABAA receptors at a site different from the sites of action of barbiturates, benzodiazepines, picrotoxin, or zinc [25–28]. It positively modulated ionotropic GABAρ1 receptors [29], and it also potentiated the currents of all the functional deletion mutants, in agreement with a presumed direct lanthanide–receptor interaction at a site capable of allosterically modulating channel properties [30].
Modulation of human GABAρ1 receptors by taurine
2008, Neuroscience ResearchPotentiation of inhibitory amino acid receptors-mediated responses by lanthanum in rat sacral dorsal commissural neurons
2006, Neurotoxicology and TeratologyLayer-specific potentiation of evoked IPSCs in rat hippocampal CA1 pyramidal cells by lanthanum
2004, Brain Research BulletinDrug interactions at GABA<inf>A</inf> receptors
2002, Progress in Neurobiology
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