Loss of large neurons and occurrence of neurofibrillary tangles in the tuberomammillary nucleus of patients with Alzheimer's disease
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Cited by (66)
The tuberomamillary nucleus in neuropsychiatric disorders
2021, Handbook of Clinical NeurologyProfound degeneration of wake-promoting neurons in Alzheimer's disease
2019, Alzheimer's and DementiaCitation Excerpt :Almost all histaminergic neurons are located in the hypothalamic TMN. Previous neuropathological reports describe TMN vulnerability to AD-tau starting at Braak stage 0 with accompanying neuronal loss [15,43–45]. However, those studies were either qualitative, did not use histaminergic-specific neuronal markers, or only analyzed neurons at rostral TMN levels.
Down syndrome
2019, Handbook of Clinical NeurologyThe roles of histamine and its receptor ligands in central nervous system disorders: An update
2017, Pharmacology and TherapeuticsCitation Excerpt :Increased CSF histamine and histamine metabolite levels in the frontal cortex, temporal cortex, basal ganglia, and hippocampus were detected in AD patients (Cacabelos et al., 1989; Fernandez-Novoa & Cacabelos, 2001), whereas others reported reduced histamine levels in the hippocampus, frontal, hypothalamus and temporal cortex of AD patients (Panula et al., 1998). AD patients typically display degeneration of histaminergic neurons in the rostral TMN (Nakamura et al., 1993; Shan, Bao, & Swaab, 2015). The amount of H1R binding is also decreased in the frontal and temporal areas of AD patients, which is significantly correlated with the severity of their cognitive symptoms (Higuchi et al., 2000).
Monoaminergic neuropathology in Alzheimer's disease
2017, Progress in NeurobiologySleep in Alzheimer's Disease–Beyond Amyloid
2017, Neurobiology of Sleep and Circadian Rhythms