Normalization of tyrosine hydroxylase activity in vivo in the striatum of transgenic mice carrying human tyrosine hydroxylase gene: a microdialysis study
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Chapter 5.1 Microdialysis in genetically altered animals
2006, Handbook of Behavioral NeuroscienceCitation Excerpt :As one of the most informative and reliable tool to measure extracellular neurotransmitter concentrations, microdialysis has shown great utility in characterization of such models. The first reports describing application of microdialysis technique to genetically altered animals are dated as early as 1993 and 1994 (Nakahara et al., 1993; Nagatsu et al., 1994), when techniques to develop transgenic mice were in infancy. These investigations give ambiguous results, however, most likely due to limitations of these early genetic approaches used to overexpress proteins of interest.
Microdialysis in freely moving mice: Determination of acetylcholine, serotonin and noradrenaline release in galanin transgenic mice
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