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Sigma-1 receptor in brain ischemia/reperfusion: Possible role in the NR2A-induced pathway to regulate brain-derived neurotrophic factor
2017, Journal of the Neurological SciencesCitation Excerpt :Therefore, they are ideally suited to upregulate a variety of processes that may affect cellular function. Although the mechanism of the interaction between σ1rs and NMDARs remains unclear, activation of σ1rs leads to the potentiation of NMDAR-mediated responses in neurons [12,13,39–44]. One possible mechanism by which NMDARs are potentiated is via the increase in the receptors expressed at the plasma membrane.
Pregnenolone as a novel therapeutic candidate in schizophrenia: Emerging preclinical and clinical evidence
2011, NeuroscienceCitation Excerpt :A number of neurosteroids demonstrate important pleiotropic actions that impact critical brain functions at physiologically relevant concentrations in rodent models. These include the modulation of inhibitory GABAergic and excitatory glutamatergic neurotransmitter systems (Wu et al., 1991; Paul and Purdy, 1992; Irwin et al., 1994; Bergeron et al., 1996; Debonnel et al., 1996; Compagnone and Mellon, 1998; Rupprecht and Holsboer, 1999; Belelli and Lambert, 2005; Belelli et al., 2006), the enhancement of neurogenesis (Mayo et al., 2005; Wang et al., 2005, 2010), microtubule assembly (Murakami et al., 2000; Fontaine-Lenoir et al., 2006; Hsu et al., 2006), dendritic outgrowth (Fontaine-Lenoir et al., 2006), and myelination (Koenig et al., 1995; Azcoitia et al., 2003; Ghoumari et al., 2003; Liao et al., 2009), regulation of the hypothalamic–pituitary–adrenal (HPA) axis (Patchev et al., 1994, 1996; Guo et al., 1995), and the reduction of apoptosis (Charalampopoulos et al., 2004, 2006; Xilouri and Papazafiri, 2006) and inflammatory responses (He et al., 2004a; VanLandingham et al., 2007; Liao et al., 2009). Many neurosteroids also exhibit pronounced neuroprotective actions against excitotoxicity (Lockhart et al., 2002; Ciriza et al., 2004; Kelley et al., 2008), neurodegeneration (Griffin et al., 2004; Ahmad et al., 2005; Xilouri and Papazafiri, 2006; Mellon et al., 2008), traumatic brain injury (TBI) (Djebaili et al., 2004, 2005; He et al., 2004b; Sayeed et al., 2009), and other insults.
The cholinergic system, sigma-1 receptors and cognition
2011, Behavioural Brain ResearchCitation Excerpt :In an electrophysiological study in which animals were unilaterally lesioned by local injection of colchicine into the mossy fiber system (an afferent system to CA3 pyramidal neurons), the potentiating effect of (+)-pentazocine on the NMDA-response was found to persist on the lesioned side, but the potentiating effects of DTG and igmesine were abolished after lesioning [21]. These data were interpreted as suggesting that the test drugs were acting on two different subtypes of sigma receptors, and that the receptors for DTG and igmesine are located on the mossy fiber terminals, in contrast to the receptors for (+)-pentazocine [21]. In a later study, the effect of the sigma-2 subtype-selective ligand siramesine was tested on the neuronal response to NMDA in the CA3 region of the rat dorsal hippocampus.
Progestogens and brain: An update
2009, MaturitasPregnenolone sulfate in the brain: A controversial neurosteroid
2008, Neurochemistry InternationalProgesterone: Therapeutic opportunities for neuroprotection and myelin repair
2007, Pharmacology and TherapeuticsCitation Excerpt :A role for the inhibition of σ1 receptor functions by progesterone has been documented in the dorsal hippocampus. Thus, the potentiation of the N-methyl-d-aspartate (NMDA) response of hippocampal neurons and the NMDA-evoked norepinephrine release from preloaded hippocampal slices by σ1 ligands, were both strongly reduced in the presence of progesterone (Monnet et al., 1995; Debonnel et al., 1996; Bergeron et al., 1999). Furthermore, progesterone has been shown to influence the behavioral efficacy of σ1 receptor ligands in mice (Phan et al., 2002; Maurice, 2004).