ReviewThe interaction of neurotensin with dopaminergic pathways in the central nervous system: Basic neurobiology and implications for the pathogenesis and treatment of schizophrenia
References (98)
- et al.
Effects of neuroleptic drugs on brain somatostatin-like-immunoreactivity
Neurosci Lett
(1984) - et al.
The isolation of a new hypotensive peptide, neurotensin, from bovine hypothalami
J Biol Chem
(1973) - et al.
Radioimmunoassay for neurotensin, a hypothalamic peptide
J Biol Chem
(1976) - et al.
Characterization of radioimmunoassayable neurotensin in the rat: its differential distribution in the central nervous system, small intestine, and stomach
J Biol Chem
(1976) - et al.
Neurotensin administered intracisternally inhibits responsiveness of mice to noxious stimuli
Eur J Pharmacol
(1977) - et al.
The regional distribution of somatostatin, substance P and neurotensin in human brain
Brain Res
(1981) - et al.
Neurotensin facilitates dopamine release in vitro from rat striatal slices
Brain Res
(1983) Cholecystokinin octapeptide levels in rat brain are changed after subchronic neuroleptic treatment
Eur J Pharmacol
(1983)- et al.
Regional distribution of bombesin and seven other regulatory peptides in the human brain
Brain Res.
(1984) - et al.
Neurotensin stimulates formation of cyclic GMP in murine neuroblastoma clone N1E-115
Eur J Pharmacol
(1984)
Neurotensin: a new ‘reward peptide’
Brain Res
Mosaic distribution of neurotensin-like immunoactivity in the cat striatum
Brain Res
Neurotensin receptors in the rat striatum: lesion studies
Brain Res
A comparative study of neurotensin inactivation by brain peptidases from different vertebrate species
Comp Biochem Physiol
Neurotensin effects on brain dopaminergic systems
Brain Res
Light and electron microscopic immunocytochemistry of neurotensin-like immunoreactive neurons in the rat hypothalamus
Brain Res
Coexistence of dopamine and neurotensin in hypothalamic arcuate and periventricular neurons
Brain Res
Evidence for the existence of a neurotensin-containing pathway from the endopiriform nucleus and the adjacent prepiriform cortex to the anterior olfactory nucleus and nucleus of diagonal band (BROCA) of the rat
Neuroscience
Distribution and origins of neurotensin-containing fibers in the nucleus ventromedialis hypothalami of the rat: an experimental immunohistochemical study
Brain Res.
Neurotensin affects hyperactivity but not stereotypy induced by pre- and post-synaptic dopaminergic stimulation
Neurosci Biobehav Rev
Behavioral and neurochemical effects of neurotensin microinjection into the ventral tegmental area of the rat
Neuroscience
Increase in spontaneous motor activity following infusion of neurotensin into the ventral tegmental area
Brain Res
Neuroanatomical site specific modulation of spontaneous motor activity by neurotensin
Eur J Pharmacol
Neurotensin microinjection into the nucleus accumbens antagonizes dopamine-induced increase in locomotion and rearing
Neuroscience
Neurotensin neurons in the ventral tegmental area project to the medial nucleus accumbens
Brain Res
Regional distribution of immunoreactive neurotensin in monkey brain
Brain Res
Regional distribution of neurotensin and somatostatin in rat brain
Brain Res
Distribution, localization, and characterization of neurotensin binding sites in the rat brain
Neuropharmacology
Substance P and neurotensin: recent progress
Horm Res
The effects of neuropeptides on discrete-trial conditioned avoidance responding
Brain Res
Monoiodo-[Trp11]-neurotensin, a highly radioactive ligand of neurotensin receptors
J Biol Chem
Neurotensin-dopamine interactions in the central nervous system
Trends Pharmacol Sci
Neurotensin potentiates the potassium-induced release of endogenous dopamine from rat striatal slices
Eur J Pharmacol
Isolated removal of hypothalamic or other brain nuclei of the rat
Brain Res
Interactions between neurotensin and dopamine in the brain: an overview
Peptides
Autoradiographic distribution of [3H]neurotensin receptors in rat brain: visualization by tritium-sensitive film
Peptides
Neurotensin interacts with dopaminergic neurons in rat brain
Peptides
An hypothesis of the molecular structure of the dopamine receptor
Med Hypotheses
Neurotensin, a central nervous system peptide: apparent receptor binding in brain membranes
Brain Res
Neurotensin-containing cell bodies, fibers, and nerve terminals in the brainstem of the rat: immonohistochemical mapping
Brain Res
Neurotensin receptor localization by light microscopic autoradiography in rat brain
Brain Res
Neurotensin in vitro markedly reduces the affinity in subcortical limbic 3H-N-propylnorapomorphine binding sites
Acta Physiol Scand
Microtopographic distribution of neurotensin and catecholamine concentrations at the level of individual rat brain nuclei
Soc Neurosci Abs
Pathophysiologic basis of tardive dyskinesia
Adv Biochem Psychopharmacol
The sites of origin of brain stem neurotensin and serotonin projections to the rodent nucleus raphe magnus
J Neurosci
Alterations in regional brain concentrations of neurotensin and bombesin in Parkinson's disease
Ann Neurol
Hypothermia and cold intolerance induced by the intracisternal administration of the hypothalamic peptide neurotensin
Nature
Ontogeny of brain neurotensin in the rat: a radio immunoassay study
J Neurochem
Cited by (158)
Role of central neurotensin in regulating feeding: Implications for the development and treatment of body weight disorders
2018, Biochimica et Biophysica Acta - Molecular Basis of DiseaseCitation Excerpt :Nts administration within the VTA mimics some effects of psychostimulant treatment, including promoting self-administration, hyperactivity and DA release to the NAc, as well as generating a conditioned place preference and locomotor sensitization [56,70,73]. Conversely, Nts in the NAc abrogates amphetamine-induced locomotion as well as “rewarding” VTA electrical self-stimulation [73,84]. At face value, these findings suggest diverging roles for Nts to promote psychostimulant reward via the VTA, or to suppress it via the NAc.
Neurotensin induced Egr-1 activity is altered in the postpartum period in mice
2012, Brain ResearchCitation Excerpt :NT is 13 amino acids long and is identical in humans and mice. NT is linked to pain sensitivity (Dubuc et al., 1999; Sarret et al., 2005), temperature regulation (Martin et al., 1980; Nemeroff et al., 1977; Remaury et al., 2002), and, in humans, NT is involved in some mental health disorders, including schizophrenia (Kinkead and Nemeroff, 2006; Nemeroff, 1986) and autism (Angelidou et al., 2010). NT is strongly linked with dopamine signaling (Binder et al., 2001) and is produced from neurons in brain regions linked to social and maternal behaviors, including preoptic area, bed nucleus of stria terminalis (BNST), nucleus accumbens, lateral septum (LS), amygdala, and periaqueductal gray (PAG) (Jennes et al., 1982; Uhl et al., 1977).
Changes in CNS response to neurotensin accompany the postpartum period in mice
2011, Hormones and BehaviorThe novel neurotensin analog NT69L blocks phencyclidine (PCP)-induced increases in locomotor activity and PCP-induced increases in monoamine and amino acids levels in the medial prefrontal cortex
2010, Brain ResearchCitation Excerpt :It is widely distributed throughout the central nervous system, with the highest concentration in the amygdale, lateral septum, substantia nigra, and ventral tegmental area (Uhl, 1982). In the CNS, NT acts as a neurotransmitter or a neuromodulator (Nemeroff, 1986). The NT system is associated with several neurotransmitter systems including dopaminergic, serotonergic, GABA-ergic, glutamatergic, and cholinergic.
Review of recent advances in analytical techniques for the determination of neurotransmitters
2009, Analytica Chimica ActaCitation Excerpt :Such neuropeptides are discussed in 4.7–4.15 below. NT is a 13 amino acid peptide that has significant interactions with the dopaminergic system [207] and is indicated to play a role in the regulation of luteinizing hormone and prolactin release [208,209]. For in vivo monitoring of NT, microdialysis coupled with RIA was used [202].
Neurotensin inversely modulates maternal aggression
2009, Neuroscience
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Dr. Nemeroff was awarded the 1985 Curt P. Richter Award of the International Society of Psychoneuroendocrinology for this article.