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The interaction of neurotensin with dopaminergic pathways in the central nervous system: Basic neurobiology and implications for the pathogenesis and treatment of schizophrenia

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  • Cited by (158)

    • Role of central neurotensin in regulating feeding: Implications for the development and treatment of body weight disorders

      2018, Biochimica et Biophysica Acta - Molecular Basis of Disease
      Citation Excerpt :

      Nts administration within the VTA mimics some effects of psychostimulant treatment, including promoting self-administration, hyperactivity and DA release to the NAc, as well as generating a conditioned place preference and locomotor sensitization [56,70,73]. Conversely, Nts in the NAc abrogates amphetamine-induced locomotion as well as “rewarding” VTA electrical self-stimulation [73,84]. At face value, these findings suggest diverging roles for Nts to promote psychostimulant reward via the VTA, or to suppress it via the NAc.

    • Neurotensin induced Egr-1 activity is altered in the postpartum period in mice

      2012, Brain Research
      Citation Excerpt :

      NT is 13 amino acids long and is identical in humans and mice. NT is linked to pain sensitivity (Dubuc et al., 1999; Sarret et al., 2005), temperature regulation (Martin et al., 1980; Nemeroff et al., 1977; Remaury et al., 2002), and, in humans, NT is involved in some mental health disorders, including schizophrenia (Kinkead and Nemeroff, 2006; Nemeroff, 1986) and autism (Angelidou et al., 2010). NT is strongly linked with dopamine signaling (Binder et al., 2001) and is produced from neurons in brain regions linked to social and maternal behaviors, including preoptic area, bed nucleus of stria terminalis (BNST), nucleus accumbens, lateral septum (LS), amygdala, and periaqueductal gray (PAG) (Jennes et al., 1982; Uhl et al., 1977).

    • The novel neurotensin analog NT69L blocks phencyclidine (PCP)-induced increases in locomotor activity and PCP-induced increases in monoamine and amino acids levels in the medial prefrontal cortex

      2010, Brain Research
      Citation Excerpt :

      It is widely distributed throughout the central nervous system, with the highest concentration in the amygdale, lateral septum, substantia nigra, and ventral tegmental area (Uhl, 1982). In the CNS, NT acts as a neurotransmitter or a neuromodulator (Nemeroff, 1986). The NT system is associated with several neurotransmitter systems including dopaminergic, serotonergic, GABA-ergic, glutamatergic, and cholinergic.

    • Review of recent advances in analytical techniques for the determination of neurotransmitters

      2009, Analytica Chimica Acta
      Citation Excerpt :

      Such neuropeptides are discussed in 4.7–4.15 below. NT is a 13 amino acid peptide that has significant interactions with the dopaminergic system [207] and is indicated to play a role in the regulation of luteinizing hormone and prolactin release [208,209]. For in vivo monitoring of NT, microdialysis coupled with RIA was used [202].

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    Dr. Nemeroff was awarded the 1985 Curt P. Richter Award of the International Society of Psychoneuroendocrinology for this article.

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