Cloning and characterization of a yeast cytochrome b5-encoding gene which suppresses ketoconazole hypersensitivity in a NADPH-P-450 reductase-deficient strain
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Analysis of cytochrome b<inf>5</inf> reductase-mediated metabolism in the phytopathogenic fungus Zymoseptoria tritici reveals novel functionalities implicated in virulence
2015, Fungal Genetics and BiologyCitation Excerpt :Additionally, it is thought to be involved in certain CYP-catalysed reactions (Lamb et al., 1999, 2001). The genome of the model yeast S. cerevisiae contains only a single copy microsomal CBR sequence (Csukai et al., 1994; Truan et al., 1994). In the previously analysed filamentous fungus M. alpina, which is used in the industrial production of arachidonic acid, two microsomal CBRs have been identified in biochemical studies and structurally characterised (Sakuradani et al., 1999; Certik et al., 1999), though their functional importance to the organism is not known and the biochemical role of the secondary CBR is also unclear.
The induction of microsomal NADPH:cytochrome P450 and NADH:cytochrome b<inf>5</inf> reductases by long-term salt treatment of cotton (Gossypium hirsutum L.) and bean (Phaseolus vulgaris L.) plants
2007, Plant Physiology and BiochemistryCitation Excerpt :Most probably, the fatty acid and sterol desaturases of the ER accept reducing equivalents from both NADH (through B5R) and NADPH (through CPR) in vivo. It has been reported that a yeast mutant deficient in either B5R or CPR was able to grow under normal conditions [6,23,27], while the disruption of both reductases was lethal [6]. Current evidence would suggest that alterations in B5R and CPR activities in plants subjected to environmental stresses may be targeted to the maintenance of the membrane lipids in optimal condition.
A cytosolic cytochrome b<inf>5</inf>-like protein in yeast cell accelerating the electron transfer from NADPH to cytochrome c catalyzed by Old Yellow Enzyme
2005, Biochemical and Biophysical Research CommunicationsThe cytochrome P450 reductase CprA is a rate-limiting factor for Cyp51A-mediated azole resistance in Aspergillus fumigatus
2023, Antimicrobial Agents and Chemotherapy