Journal of Chromatography B: Biomedical Sciences and Applications
Sensitive gas—liquid chromatographic method for the determination of loratadine and its major active metabolite, descarboethoxyloratadine, in human plasma using a nitrogen—phosphorus detector
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2022, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life SciencesCitation Excerpt :Different analytical techniques have been reported for determination of the MONT, including HPLC [12–14], TLC [15,16] and differential pulse voltammetry [17]. While LOR was determined by HPLC [18–22], TLC [23–26], gas chromatography [27], capillary electrophoresis [28,29] and spectrofluorometry [30–33]. The reported methods for the simultaneous determination of MONT and LOR were HPLC [34] and derivative spectrophotometry [34,35].
Development of novel electrochemical sensor on the base of molecular imprinted polymer decorated on SiC nanoparticles modified glassy carbon electrode for selective determination of loratadine
2017, Materials Science and Engineering CCitation Excerpt :It is widely used for the relief of allergic seasonal symptom, such as sneezing, watery eyes, skin rash, itching, hives and runny nose. In the literature, different analytical procedures were reported for determination of LOT; including spectrophotometry [2,3], electrochemistry [4], densitometry [5], fluorescence [6], capillary electrophoresis [7,8] and chromatography [9–15]. Among the various reported methods, the electrochemical methods are viable alternatives for determination of LOT in pharmaceutical formulations due to some advantages, such as simplicity of operation, selectivity, having inexpensive techniques with high speed, and rapidity of data acquisition which makes them very competitive methods and usually the best choice for determination of electro-active compounds, and being suitable for routine analysis.
Novel spectrophotometric methods for determination of desloratidine in pharmaceutical formulations based on charge transfer reaction
2016, Arabian Journal of ChemistryLC-ESI-MS/MS estimation of loratadine-loaded self-nanoemulsifying drug delivery systems in rat plasma: Pharmacokinetic evaluation and computer simulations by GastroPlus™
2016, Journal of Pharmaceutical and Biomedical AnalysisAnalysis for commonly prescribed non-sedating antihistamines
2015, Analytical Chemistry ResearchCitation Excerpt :A validated GC/MS method for determination of total amount of KET in human plasma has been described using pizotifen as an internal standard (IS) [160]. Furthermore, a sensitive gas–liquid chromatographic (GLC) method has been developed for the determination of LOR and its active metabolite in human plasma, using a nitrogen-phosphorus detector and a fused-silica capillary column [161]. GC/MS method for the determination of LOR and pheniramine in human serum has been developed [162].
Extraction optimization of Loratadine by supramolecular solvent-based microextraction and its determination using HPLC
2015, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life SciencesCitation Excerpt :A very important feature of this generation of antihistamines is that when used at therapeutic concentrations they have a poorly expressed sedating effect, because only small amounts of the drugs penetrate the blood–brain barrier [2]. Several methods have been reported in the literature for determination of Loratadine in pharmaceutical preparations including spectrophotometry [3–5], polarography [6,7], densitometry [8], capillary electrophoresis [9], gas chromatography [10,11] and HPLC [12–23]. HPLC is the most common method that is used for separation and determination of Loratadine.