Research paperAn HPLC and spectrophotometric study of the hydrolysis of ICRF-187 (dexrazoxane, (+)-1,2-bis(3,5-dioxopiperazinyl-1-yl)propane) and its one-ring opened intermediates
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Cited by (38)
Interface-free capillary electrophoresis-mass spectrometry system with nanospray ionization—Analysis of dexrazoxane in blood plasma
2016, Journal of Chromatography ACitation Excerpt :It should be noted that for analysis of dexrazoxane and its metabolite the ammonium cations must be added in the form of a salt to sustain acidic (or neutral) pH of the solution. Addition of ammonia would increase pH resulting in dramatic increase of the dexrazoxane hydrolysis during the sample storage and handling [36]. We have observed that the ADR-925/Dexrazoxane ratio was shifted within 7 analyses (70 min) more than 5 times towards the ADR-925.
Hydrophilic interaction liquid chromatography in the separation of a moderately lipophilic drug from its highly polar metabolites-the cardioprotectant dexrazoxane as a model case
2011, Journal of Chromatography ACitation Excerpt :1H NMR (300 MHz, DMSO, Varian Mercury-Vx BB 300 instrument): δ 7.71 (1H; s; NH2); 7.49 (1H; s; NH2); 7.25 (1H; s; NH2); 7.15 (1H; s; NH2); 3.31–3.07 (9H; m; 4× CH2, CH); 2.92–2.85 (1H; m; CH2); 2.68–.61 (1H; m; CH2); 0.90 (3H; d; J = 6.5 Hz); 13C NMR (75 MHz, DMSO): δ 173.4; 173.1; 172.9; 172.5; 57.6; 55.6; 55.2; 54.4; 53.6; 53.3; 12.9. A mixture containing intermediates B and C was prepared by alkaline hydrolysis as described previously [19]. After quenching the hydrolysis, the presence of the intermediates was tested by direct infusion of the diluted sample solution (approx. 2 μg/mL) into the ESI–MS source. [
The iron chelating cardioprotective prodrug dexrazoxane does not affect the cell growth inhibitory effects of bleomycin
2004, Journal of Inorganic BiochemistryHigh-performance liquid chromatographic methods for the determination of topoisomerase II inhibitors
2001, Journal of Chromatography B: Biomedical Sciences and ApplicationsDexrazoxane (ICRF-187)
1999, General Pharmacology
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