Research paper
Hepatoprotective effects of emodin from Ventilago leiocarpa

https://doi.org/10.1016/0378-8741(96)01397-9Get rights and content

Abstract

A major component of ethyl acetate (EtOAc) and chloroform (CHCl3) fractions of Ventilago leiocarpa Bunge (Rhamnaceae), emodin, was isolated and exhibited hepatoprotective effects on carbon tetrachloride (CCl4) as well as d-galactosamine (D-GalN)-induced liver damage. The histopathological examination also clearly showed that emodin reduced lymphocyte cells, Kupffer cells, ballooning degeneration, cell necrosis and hyaline degeneration on CCl4 and d-galactosamine-induced tests.

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    Emodin has been used as a traditional Chinese medicine for over 2000 years and is still present in various herbal preparations. Moreover, emerging evidences indicate that emodin possessed a wide spectrum of pharmacological properties, including anticancer, hepatoprotective, anti-inflammatory, antioxidant and antimicrobial activities [23–25]. Most recently, we demonstrated that emodin could increase the immune and antioxidant capacity in aquatic animals, especially M. amblycephala [26].

  • Inclusion complex of emodin with hydroxypropyl-β-cyclodextrin: Preparation, physicochemical and biological properties

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    Emodin (Fig. 1a) is a herbal anthraquinone derivative isolated from the rhizome of Rheum palmatum, which has been widely used as a laxative in traditional Chinese medicine [1,2]. It is an important and effective polyphenols with a wide range of biological activities, such as hepatoprotective [3], anti-inflammatory [4], anti-diabetic [5], immunosuppressive [6], anti-ulcerogenic [7] and anti-tumor [8]. Numerous studies have reported that emodin exhibited anti-cancer activity on many type of human cancers, including lung cancer [9], cervical cancer [10], pancreatic cancer [11], leukemia [12], colon cancer [13] and breast cancer [14].

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