Free radical formation by antitumor quinones

doi:10.1016/0891-5849(89)90162-7

Free Radical Biology and Medicine

Volume 6, Issue 1, 1989, Pages 63-101

https://doi.org/10.1016/0891-5849(89)90162-7 Get rights and content

Abstract

Quinones are among the most frequently used drugs to treat human cancer. All of the antitumor quinones can undergo reversible enzymatic reduction and oxidation, and form semiquinone and oxygen radicals. For several antitumor quinones enzymatic reduction also leads to formation of alkylating species but whether this involves reduction to the semiquinone or the hydroquinone is not always clear. The antitumor activity of quinones is frequently linked to DNA damage caused by alkylating species or oxygen radicals. Some other effects of the antitumor quinones, such as cardiotoxicity and skin toxicity, may also be related to oxygen radical formation. The evidence for a relationship between radical formation and the biological activity of the antitumor quinones is evaluated.

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^∗: Garth Powis, D.Phil., is a native of England and was trained in Biochemistry and Physiology and Oxford University, U.K., before becoming a University Lecturer in Pharmacology at Glasgow University, U.K. In 1977 he moved to the U.S.A. and became Professor of Pharmacology and Consultant of Oncology at the Mayo Clinic and Foundation, Rochester, Minnesota. His research interests are the metabolism and mechanisms of actions of anticancer drugs with particular emphasis on antitumor quinones. His current work is involved with human metabolism of anticancer drugs and their extranuclear actions.

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Review articleFree radical formation by antitumor quinones

Abstract

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J. Biol. Chem.

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Cancer Chemother. Rep.

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Drugs Expl. Clin. Res.

Review article
Free radical formation by antitumor quinones