Original contributionOxidative stress by acute acetaminophen administration in mouse liver
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2021, Science of the Total EnvironmentCitation Excerpt :Moreover, urinary concentrations of AAP (unintentional exposure via diet) were reported to be associated with longer time to pregnancy (median: 26.6 and 13.2 ng/mL for females and males, respectively) (Smarr et al., 2016) and lower semen quality (15.5 ng/mL [interquartile range 5.44, 73.5]) (Smarr et al., 2017) in males. AAP has been known to induce mitochondria dysfunction (Jaeschke et al., 2012; Umbaugh et al., 2021), oxidative stress (Lores Arnaiz et al., 1995; Wang et al., 2017), and inflammatory responses (Jaeschke and Ramachandran, 2020) in the pathogenesis of AAP hepatotoxicity (Shan et al., 2018). Various studies in cells and animals such as human beings, rabbits, rats, and mice, have identified that oxidative stress plays a critical role in the toxic effects induced by AAP (Wang et al., 2017).
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2020, JHEP ReportsCitation Excerpt :Furthermore, even control animals exhibited a decrease in the concentrations of reduced GSH, albeit not reaching significance after androstanol treatment. Recently, bile acids, as well as Gstp1/2 deletion, were shown to cause resistance to APAP toxicity.33–36 Thus, bile acids and CAR-driven mechanisms may protect the DKO mice from APAP toxicity.
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